5-bromo-2-phenylthio-1,3-oxazole

Base Information

• Chemical Name: 5-bromo-2-phenylthio-1,3-oxazole
• CAS No.: 1226781-97-0
• Molecular Formula: C₉H₆BrNOS
• Molecular Weight: 256.123
• Mol file: 1226781-97-0.mol

Synonyms:5-bromo-2-phenylthio-1,3-oxazole

Chemical Property of 5-bromo-2-phenylthio-1,3-oxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-2-phenylthio-1,3-oxazole

There total 1 articles about 5-bromo-2-phenylthio-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-(phenylthio)-1,3-oxazole (1208129-40-1) → 5-bromo-2-phenylthio-1,3-oxazole (1226781-97-0)

Guidance literature:

With bromine; triethylamine; In dichloromethane; at 0 - 22 ℃;

DOI:10.1055/S-0029-1219374

Reference yield: 89.0%

5-bromo-2-phenylthio-1,3-oxazole (1226781-97-0) + triisopropylsilyl trifluoromethanesulfonate (80522-42-5) → C18H26BrNOSSi (1226782-02-0)

Guidance literature:

5-bromo-2-phenylthio-1,3-oxazole; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 0 ℃;

triisopropylsilyl trifluoromethanesulfonate; In tetrahydrofuran; at -78 - 22 ℃; regioselective reaction;

DOI:10.1055/S-0029-1219374

Reference yield: 89.0%

5-bromo-2-phenylthio-1,3-oxazole (1226781-97-0) → 4-bromo-2-(phenylthio)oxazole (1226781-99-2)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 0.833333h;

DOI:10.1021/acs.orglett.0c02188

upstream raw materials:

2-(phenylthio)-1,3-oxazole

Downstream raw materials:

C₁₈H₁₂N₂O₄S₂

C₁₄H₁₀BrNO₃S

C₁₀H₈BrNO₂S

C₁₅H₁₀BrNOS