ethyl 6-[({2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1,7-dimethyl-1H-indole-2-carboxylate

Base Information

Chemical Name:ethyl 6-[({2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1,7-dimethyl-1H-indole-2-carboxylate
CAS No.:1314128-77-2
Molecular Formula:C₂₅H₂₇FN₂O₅
Molecular Weight:454.498
Hs Code.:

Synonyms:ethyl 6-[({2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1,7-dimethyl-1H-indole-2-carboxylate

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Chemical Property of ethyl 6-[({2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1,7-dimethyl-1H-indole-2-carboxylate

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Technology Process of ethyl 6-[({2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1,7-dimethyl-1H-indole-2-carboxylate

There total 10 articles about ethyl 6-[({2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1,7-dimethyl-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1224719-48-5
2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzoic acid

: 1314128-65-8
ethyl 6-amino-1,7-dimethyl-1H-indole-2-carboxylate

: 1314128-77-2
ethyl 6-[({2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1,7-dimethyl-1H-indole-2-carboxylate

Guidance literature:: 2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 2h;

ethyl 6-amino-1,7-dimethyl-1H-indole-2-carboxylate; With triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 603-83-8
3-nitro-o-tolylamine

: 1314128-77-2
ethyl 6-[({2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1,7-dimethyl-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; sodium nitrite / acetonitrile; water / 0.5 h / -10 - -5 °C

1.2: 0.17 h / -6 - 2 °C

1.3: 1 h / 0 °C

2.1: methanesulfonic acid; Eaton′s Reagent / toluene / 0.33 h / 80 °C

3.1: sodium hydride / N,N-dimethyl-formamide; Pionier 2076 / 1.5 h / 0 - 20 °C

4.1: hydrogen / palladium-on-charcoal / ethyl acetate / 18 h / 20 °C / 760.05 Torr

5.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

5.2: 20 °C

With hydrogenchloride; oxalyl dichloride; methanesulfonic acid; Eaton′s Reagent; hydrogen; sodium hydride; sodium nitrite; palladium-on-charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; Pionier 2076; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1314128-63-6
ethyl 1,7-dimethyl-6-nitro-1H-indole-2-carboxylate

: 1314128-77-2
ethyl 6-[({2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1,7-dimethyl-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium-on-charcoal / ethyl acetate / 18 h / 20 °C / 760.05 Torr

2.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

2.2: 20 °C

With oxalyl dichloride; hydrogen; palladium-on-charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; ethyl acetate;