2-fluoro-N-[2-(hydroxymethyl)-1,7-dimethyl-1H-indol-6-yl]-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Base Information

Chemical Name:2-fluoro-N-[2-(hydroxymethyl)-1,7-dimethyl-1H-indol-6-yl]-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide
CAS No.:1314128-78-3
Molecular Formula:C₂₃H₂₅FN₂O₄
Molecular Weight:412.461
Hs Code.:

Synonyms:2-fluoro-N-[2-(hydroxymethyl)-1,7-dimethyl-1H-indol-6-yl]-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

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Chemical Property of 2-fluoro-N-[2-(hydroxymethyl)-1,7-dimethyl-1H-indol-6-yl]-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

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Technology Process of 2-fluoro-N-[2-(hydroxymethyl)-1,7-dimethyl-1H-indol-6-yl]-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

There total 12 articles about 2-fluoro-N-[2-(hydroxymethyl)-1,7-dimethyl-1H-indol-6-yl]-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1314128-77-2
ethyl 6-[({2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1,7-dimethyl-1H-indole-2-carboxylate

: 1314128-78-3
2-fluoro-N-[2-(hydroxymethyl)-1,7-dimethyl-1H-indol-6-yl]-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Guidance literature:: ethyl 6-[({2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1,7-dimethyl-1H-indole-2-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

With hydrogenchloride; Glauber's salt; water; In tetrahydrofuran;

Reference yield:

: 603-83-8
3-nitro-o-tolylamine

: 1314128-78-3
2-fluoro-N-[2-(hydroxymethyl)-1,7-dimethyl-1H-indol-6-yl]-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; sodium nitrite / acetonitrile; water / 0.5 h / -10 - -5 °C

1.2: 0.17 h / -6 - 2 °C

1.3: 1 h / 0 °C

2.1: methanesulfonic acid; Eaton′s Reagent / toluene / 0.33 h / 80 °C

3.1: sodium hydride / N,N-dimethyl-formamide; Pionier 2076 / 1.5 h / 0 - 20 °C

4.1: hydrogen / palladium-on-charcoal / ethyl acetate / 18 h / 20 °C / 760.05 Torr

5.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

5.2: 20 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; oxalyl dichloride; methanesulfonic acid; Eaton′s Reagent; hydrogen; sodium hydride; sodium nitrite; palladium-on-charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; Pionier 2076; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1314128-65-8
ethyl 6-amino-1,7-dimethyl-1H-indole-2-carboxylate

: 1314128-78-3
2-fluoro-N-[2-(hydroxymethyl)-1,7-dimethyl-1H-indol-6-yl]-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

1.2: 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C

With lithium aluminium tetrahydride; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran;