(1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenylcarbamate

Base Information

• Chemical Name: (1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenylcarbamate
• CAS No.: 304015-67-6
• Molecular Formula: C₁₉H₂₈N₄O₅Si
• Molecular Weight: 420.541
• Mol file: 304015-67-6.mol

Synonyms:(1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenylcarbamate

Chemical Property of (1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenylcarbamate

There total 1 articles about (1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-[(tert-butyldimethylsilyloxy)methyl]aniline (131230-76-7) + (1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-nitrophenyl carbonate (263159-60-0) → (1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenylcarbamate (304015-67-6)

Guidance literature:

With 4 A molecular sieve; benzotriazol-1-ol; triethylamine; In tetrahydrofuran; at 20 ℃; for 48h;

DOI:10.1016/j.bmc.2005.03.055

Reference yield: 47.0%

(1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenylcarbamate (304015-67-6) → (1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-(hydroxymethyl)phenylcarbamate (304015-69-8)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2005.03.055

Reference yield:

(1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenylcarbamate (304015-67-6) → 4-({[(1-methyl-5-nitro-1H-imidazol-2-yl)methoxy]carbonyl}amino)benzyl 4-nitrophenyl carbonate (304015-70-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / hydrochloric acid / methanol / 1 h / 20 °C

2: 63 percent / ethyldiisopropylamine / tetrahydrofuran / 16 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmc.2005.03.055

upstream raw materials:

4-[(tert-butyldimethylsilyloxy)methyl]aniline

(1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-nitrophenyl carbonate

Downstream raw materials:

(1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-(hydroxymethyl)phenylcarbamate

4-({[(1-methyl-5-nitro-1H-imidazol-2-yl)methoxy]carbonyl}amino)benzyl 4-nitrophenyl carbonate