3,5-difluoro-4-[4-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-piperazin-1-yl]-phenylamine

Base Information

Chemical Name:3,5-difluoro-4-[4-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-piperazin-1-yl]-phenylamine
CAS No.:1188400-81-8
Molecular Formula:C₁₃H₁₈F₂N₃O₃P
Molecular Weight:333.275
Hs Code.:

Synonyms:3,5-difluoro-4-[4-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-piperazin-1-yl]-phenylamine

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Chemical Property of 3,5-difluoro-4-[4-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-piperazin-1-yl]-phenylamine

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Technology Process of 3,5-difluoro-4-[4-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-piperazin-1-yl]-phenylamine

There total 4 articles about 3,5-difluoro-4-[4-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-piperazin-1-yl]-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1188400-80-7
1-(2,6-difluoro-4-nitro-phenyl)-4-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-piperazine

: 1188400-81-8
3,5-difluoro-4-[4-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-piperazin-1-yl]-phenylamine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; Inert atmosphere;

Reference yield:

: 864072-82-2
1-(2,6-difluoro-4-nitro-phenyl)-piperazine

: 1188400-81-8
3,5-difluoro-4-[4-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-piperazin-1-yl]-phenylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / dichloromethane / -78 - 0 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0 °C / Inert atmosphere

2.2: 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / Inert atmosphere

With n-butyllithium; hydrogen; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; hexane; dichloromethane;

Reference yield:

: 66684-58-0
3,4,5-trifluoronitrobenzene

: 1188400-81-8
3,5-difluoro-4-[4-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-piperazin-1-yl]-phenylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetonitrile / 60 °C

2.1: trichlorophosphate / dichloromethane / -78 - 0 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0 °C / Inert atmosphere

3.2: 20 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / Inert atmosphere

With n-butyllithium; hydrogen; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; hexane; dichloromethane; acetonitrile;