(4-(4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone

Base Information

Chemical Name:(4-(4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone
CAS No.:1401423-22-0
Molecular Formula:C₂₀H₂₁F₄N₅O₃
Molecular Weight:455.412
Hs Code.:

Synonyms:(4-(4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone

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Chemical Property of (4-(4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone

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Technology Process of (4-(4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone

There total 4 articles about (4-(4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 110-91-8,99108-56-2
morpholine

: 1001346-91-3
4-amino-2-fluoro-5-methoxy-benzoic acid

: 1050602-61-3
2-chloro-N-cyclopropyl-5-(trifluoromethyl)pyrimidin-4-amine

: 1401423-22-0
(4-(4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone

Guidance literature:: 4-amino-6-fluoro-3-methoxy-benzoic acid; 2-chloro-N-cyclopropyl-5-(trifluoromethyl)pyrimidin-4-amine; With toluene-4-sulfonic acid; In 1,4-dioxane; at 100 ℃; for 5h;

morpholine; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 1401423-44-6
C₁₆H₁₄F₄N₄O₃

: 1401423-22-0
(4-(4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1021/jm301020q

Reference yield:

: 3932-97-6
2,4-dichloro-5-trifluoromethylpyrimidine

: 1401423-22-0
(4-(4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 4 h / 0 - 20 °C

2: toluene-4-sulfonic acid / 1,4-dioxane / 2 h / 100 °C

3: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 1 h / 0 - 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm301020q