1001346-91-3 Usage
Uses
Used in Pharmaceutical Synthesis:
4-Amino-2-fluoro-5-methoxybenzoic acid is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into complex organic molecules. Its presence in the molecular structure can influence the pharmacokinetics and pharmacodynamics of the resulting compounds, potentially enhancing their therapeutic efficacy.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 4-Amino-2-fluoro-5-methoxybenzoic acid is utilized as a building block for the development of new drug candidates. Its unique combination of functional groups allows for the creation of diverse chemical entities that can be optimized for specific biological targets.
Used in Drug Development:
4-Amino-2-fluoro-5-methoxybenzoic acid is employed in drug development as a precursor to potential therapeutic agents. Its structural features can be leveraged to design molecules with improved potency, selectivity, and pharmacological properties, contributing to the advancement of novel treatments for various diseases.
Used in Organic Chemistry:
Beyond its pharmaceutical applications, 4-Amino-2-fluoro-5-methoxybenzoic acid is also used in organic chemistry as a versatile reagent or substrate in various chemical reactions. Its presence can facilitate the synthesis of a wide range of organic compounds for use in different industries, including materials science, agrochemicals, and specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 1001346-91-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,1,3,4 and 6 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1001346-91:
(9*1)+(8*0)+(7*0)+(6*1)+(5*3)+(4*4)+(3*6)+(2*9)+(1*1)=83
83 % 10 = 3
So 1001346-91-3 is a valid CAS Registry Number.
InChI:InChI=1S/C8H8FNO3/c1-13-7-2-4(8(11)12)5(9)3-6(7)10/h2-3H,10H2,1H3,(H,11,12)
1001346-91-3Relevant academic research and scientific papers
METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION
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, (2021/04/02)
Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1)
Nie, Zhe,Feher, Victoria,Natala, Srinivasa,McBride, Christopher,Kiryanov, Andre,Jones, Benjamin,Lam, Betty,Liu, Yan,Kaldor, Stephen,Stafford, Jeffrey,Hikami, Kouki,Uchiyama, Noriko,Kawamoto, Tomohiro,Hikichi, Yuichi,Matsumoto, Shin-Ichi,Amano, Nobuyuki,Zhang, Lilly,Hosfield, David,Skene, Robert,Zou, Hua,Cao, Xiaodong,Ichikawa, Takashi
, p. 3662 - 3666 (2013/07/05)
Using structure-based drug design, we identified and optimized a novel series of pyrimidodiazepinone PLK1 inhibitors resulting in the selection of the development candidate TAK-960. TAK-960 is currently undergoing Phase I evaluation in adult patients with
POLO-LIKE KINASE INHIBITORS
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Page/Page column 266, (2009/05/29)
Compounds of the following formula are provided for use with kinases: (I) wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates use
NOVEL COMPOUNDS
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Page/Page column 134, (2008/06/13)
There is provided a compound of formula (I): processes for the manufacture thereof, pharmaceutical compositions thereof and uses in therapy.
