(S)-2-(1,3-dioxoisoindolin-2-yl)-3-phenyl-N-(quinolin-8-yl)propanamide

Base Information

• Chemical Name: (S)-2-(1,3-dioxoisoindolin-2-yl)-3-phenyl-N-(quinolin-8-yl)propanamide
• CAS No.: 908129-34-0
• Molecular Formula: C₂₆H₁₉N₃O₃
• Molecular Weight: 421.455
• Mol file: 908129-34-0.mol

Synonyms:(S)-2-(1,3-dioxoisoindolin-2-yl)-3-phenyl-N-(quinolin-8-yl)propanamide

Chemical Property of (S)-2-(1,3-dioxoisoindolin-2-yl)-3-phenyl-N-(quinolin-8-yl)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(1,3-dioxoisoindolin-2-yl)-3-phenyl-N-(quinolin-8-yl)propanamide

There total 11 articles about (S)-2-(1,3-dioxoisoindolin-2-yl)-3-phenyl-N-(quinolin-8-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

8-amino quinoline (578-66-5) + phthaloyl-L-phenylalanyl chloride (32150-91-7) → (S)-2-(1,3-dioxoisoindolin-2-yl)-3-phenyl-N-(quinolin-8-yl)propanamide (908129-34-0)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃;

DOI:10.1002/anie.201200731

Reference yield: 88.0%

(S)-2-(1,3-dioxoisoindolin-2-yl)-N-(quinolin-8-yl)propanamide (908129-33-9) + iodobenzene (591-50-4) → (S)-2-(1,3-dioxoisoindolin-2-yl)-3-phenyl-N-(quinolin-8-yl)propanamide (908129-34-0)

Guidance literature:

With palladium diacetate; silver trifluoroacetate; In water; 1,1,2,2-tetrachloroethane; at 25 ℃; for 48h; Time; Temperature; Solvent; Reagent/catalyst;

DOI:10.1039/c4sc01545b

Reference yield:

8-hydrazinoquinoline (14148-42-6) + Nα-phthaloyl-L-phenylalanine (5123-55-7) → (S)-2-(1,3-dioxoisoindolin-2-yl)-3-phenyl-N-(quinolin-8-yl)propanamide (908129-34-0)

Guidance literature:

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; for 2h;

upstream raw materials:

8-amino quinoline

phthaloyl-L-phenylalanyl chloride

phthalic anhydride

L-phenylalanine

Downstream raw materials:

2S,3S-N-(2-phthalimido-3-phenyl-3-(thiophene-2-yl)propionyl)-8-aminoquinoline

C₂₆H₁₈⁽²⁾HN₃O₃