N-benzyloxy-2-[(4-chloro-benzyl)-(toluene-4-sulfonyl)-amino]-3-phenyl-propionamide

Base Information

Chemical Name:N-benzyloxy-2-[(4-chloro-benzyl)-(toluene-4-sulfonyl)-amino]-3-phenyl-propionamide
CAS No.:245365-18-8
Molecular Formula:C₃₀H₂₉ClN₂O₄S
Molecular Weight:549.09
Hs Code.:

<i>N</i>-benzyloxy-2-[(4-chloro-benzyl)-(toluene-4-sulfonyl)-amino]-3-phenyl-propionamide

Synonyms:N-benzyloxy-2-[(4-chloro-benzyl)-(toluene-4-sulfonyl)-amino]-3-phenyl-propionamide

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Chemical Property of N-benzyloxy-2-[(4-chloro-benzyl)-(toluene-4-sulfonyl)-amino]-3-phenyl-propionamide

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Technology Process of N-benzyloxy-2-[(4-chloro-benzyl)-(toluene-4-sulfonyl)-amino]-3-phenyl-propionamide

There total 6 articles about N-benzyloxy-2-[(4-chloro-benzyl)-(toluene-4-sulfonyl)-amino]-3-phenyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124312-50-1
tert-butyl tosyl-L-phenylalaninate

: 245365-18-8
N-benzyloxy-2-[(4-chloro-benzyl)-(toluene-4-sulfonyl)-amino]-3-phenyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / polymer-supported phosphazene - BEMP on polystyrene / CH₂Cl₂

2: TFA / CH₂Cl₂

3: CBr₄, NEt₃, polymer-supported triphenylphosphine / CH₂Cl₂

With polystyrene-bound 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; PS-triphenylphosphine; carbon tetrabromide; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(99)00311-X

Reference yield:

: 15100-75-1,75898-47-4
L-phenylalanine tert-butyl ester hydrochloride

: 245365-18-8
N-benzyloxy-2-[(4-chloro-benzyl)-(toluene-4-sulfonyl)-amino]-3-phenyl-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / pyridine

2: 100 percent / polymer-supported phosphazene - BEMP on polystyrene / CH₂Cl₂

3: TFA / CH₂Cl₂

4: CBr₄, NEt₃, polymer-supported triphenylphosphine / CH₂Cl₂

With pyridine; polystyrene-bound 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; PS-triphenylphosphine; carbon tetrabromide; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(99)00311-X

Reference yield:

: 622-95-7
4-chlorobenzyl bromide

: 245365-18-8
N-benzyloxy-2-[(4-chloro-benzyl)-(toluene-4-sulfonyl)-amino]-3-phenyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / polymer-supported phosphazene - BEMP on polystyrene / CH₂Cl₂

2: TFA / CH₂Cl₂

3: CBr₄, NEt₃, polymer-supported triphenylphosphine / CH₂Cl₂

With polystyrene-bound 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; PS-triphenylphosphine; carbon tetrabromide; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(99)00311-X