isopropyl (S)-2-(2,5-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate

Base Information

• Chemical Name: isopropyl (S)-2-(2,5-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate
• CAS No.: 945635-16-5
• Molecular Formula: C₁₄H₁₇NO₄S
• Molecular Weight: 295.359

Synonyms:isopropyl (S)-2-(2,5-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate

Chemical Property of isopropyl (S)-2-(2,5-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate

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Technology Process of isopropyl (S)-2-(2,5-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate

There total 1 articles about isopropyl (S)-2-(2,5-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(S)-4,5-dihydro-2-(2,5-dihydroxyphenyl)-4-methyl-4-thiazolecarboxylic acid (917955-19-2) + 2-iodo-propane (75-30-9) → isopropyl (S)-2-(2,5-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate (945635-16-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

DOI:10.1021/jm070214s

Reference yield: 52.0%

isopropyl (S)-2-(2,5-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate (945635-16-5) + triethylene glucol monomethyl ether (112-35-6,95507-80-5) → isopropyl (S)-4,5-dihydro-2-[2-hydroxy-5-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylate (945635-18-7)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1021/jm070214s

Reference yield: 35.0%

isopropyl (S)-2-(2,5-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate (945635-16-5) + 1-Iodooctane (629-27-6) → isopropyl (S)-4,5-dihydro-2-[2-hydroxy-5-(octyloxy)phenyl]-4-methyl-4-thiazolecarboxylate (1067643-02-0)

Guidance literature:

With sodium isopropylate; In isopropyl alcohol; at 70 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jm8003398

upstream raw materials:

(S)-4,5-dihydro-2-(2,5-dihydroxyphenyl)-4-methyl-4-thiazolecarboxylic acid

2-iodo-propane

Downstream raw materials:

isopropyl (S)-4,5-dihydro-2-[2-hydroxy-5-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylate

(S)-4,5-dihydro-2-[2-hydroxy-5-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylic acid

isopropyl (S)-4,5-dihydro-2-[2-hydroxy-5-(octyloxy)phenyl]-4-methyl-4-thiazolecarboxylate

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