C₁₀H₁₂IN

Base Information

• Chemical Name: C₁₀H₁₂IN
• CAS No.: 1266052-57-6
• Molecular Formula: C₁₀H₁₂IN
• Molecular Weight: 273.116
• Mol file: 1266052-57-6.mol

Synonyms:C₁₀H₁₂IN

Chemical Property of C₁₀H₁₂IN

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₀H₁₂IN

There total 2 articles about C₁₀H₁₂IN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-dimethyl-4-[(1E)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethenyl]aniline (1190375-91-7) → C10H12IN (1266052-57-6)

Guidance literature:

N,N-dimethyl-4-[(1E)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethenyl]aniline; With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 0.166667h; Inert atmosphere;

With iodine; In tetrahydrofuran; water; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jacs.0c07854

Reference yield:

4'-dimethylaminoacetophenone (2124-31-4) → C10H12IN (1266052-57-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diphenyl(methyl)phosphine; chloro(1,5-cyclooctadiene)rhodium(I) dimer / tetrahydrofuran / 0.17 h / 20 °C / Glovebox; Inert atmosphere

1.2: 0.17 h / 20 °C / Glovebox; Inert atmosphere

1.3: 5 h / 70 °C / Sealed tube; Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran; water / 0.17 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; diphenyl(methyl)phosphine; sodium hydroxide; In tetrahydrofuran; water;

DOI:10.1021/jacs.0c07854

Reference yield: 35.0%

N2-[(dimethylamino)methylene]-8-vinyl-2'-deoxyguanosine (1140234-13-4) + C10H12IN (1266052-57-6) → C25H31N7O4 (1266052-65-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium acetate; In N,N-dimethyl-formamide; at 100 ℃; for 8h;

DOI:10.1016/j.tetlet.2010.11.053

upstream raw materials:

4'-dimethylaminoacetophenone

N,N-dimethyl-4-[(1E)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethenyl]aniline

Downstream raw materials:

C₂₅H₃₁N₇O₄