(6R,7S,10R)-4-[(2S,4S)-5-[2-((2S,6R)-6-Benzyloxymethyl-4,4-dimethoxy-tetrahydro-pyran-2-ylmethyl)-[1,3]dithian-2-yl]-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-5-methyl-hexyl]-7-isopropyl-10-methyl-1,5-dioxa-spiro[5.5]undec-3-en-2-one

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Chemical Name:(6R,7S,10R)-4-[(2S,4S)-5-[2-((2S,6R)-6-Benzyloxymethyl-4,4-dimethoxy-tetrahydro-pyran-2-ylmethyl)-[1,3]dithian-2-yl]-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-5-methyl-hexyl]-7-isopropyl-10-methyl-1,5-dioxa-spiro[5.5]undec-3-en-2-one
CAS No.:297135-61-6
Molecular Formula:C₄₆H₇₆O₉S₂Si
Molecular Weight:865.322
Hs Code.:

(6R,7S,10R)-4-[(2S,4S)-5-[2-((2S,6R)-6-Benzyloxymethyl-4,4-dimethoxy-tetrahydro-pyran-2-ylmethyl)-[1,3]dithian-2-yl]-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-5-methyl-hexyl]-7-isopropyl-10-methyl-1,5-dioxa-spiro[5.5]undec-3-en-2-one

Synonyms:(6R,7S,10R)-4-[(2S,4S)-5-[2-((2S,6R)-6-Benzyloxymethyl-4,4-dimethoxy-tetrahydro-pyran-2-ylmethyl)-[1,3]dithian-2-yl]-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-5-methyl-hexyl]-7-isopropyl-10-methyl-1,5-dioxa-spiro[5.5]undec-3-en-2-one

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Chemical Property of (6R,7S,10R)-4-[(2S,4S)-5-[2-((2S,6R)-6-Benzyloxymethyl-4,4-dimethoxy-tetrahydro-pyran-2-ylmethyl)-[1,3]dithian-2-yl]-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-5-methyl-hexyl]-7-isopropyl-10-methyl-1,5-dioxa-spiro[5.5]undec-3-en-2-one

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Technology Process of (6R,7S,10R)-4-[(2S,4S)-5-[2-((2S,6R)-6-Benzyloxymethyl-4,4-dimethoxy-tetrahydro-pyran-2-ylmethyl)-[1,3]dithian-2-yl]-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-5-methyl-hexyl]-7-isopropyl-10-methyl-1,5-dioxa-spiro[5.5]undec-3-en-2-one

There total 20 articles about (6R,7S,10R)-4-[(2S,4S)-5-[2-((2S,6R)-6-Benzyloxymethyl-4,4-dimethoxy-tetrahydro-pyran-2-ylmethyl)-[1,3]dithian-2-yl]-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-5-methyl-hexyl]-7-isopropyl-10-methyl-1,5-dioxa-spiro[5.5]undec-3-en-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121352-88-3
[(2R,3R)-3-(2-Benzyloxy-1,1-dimethyl-ethyl)-oxiranyl]-methanol

: 297135-61-6
(6R,7S,10R)-4-[(2S,4S)-5-[2-((2S,6R)-6-Benzyloxymethyl-4,4-dimethoxy-tetrahydro-pyran-2-ylmethyl)-[1,3]dithian-2-yl]-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-5-methyl-hexyl]-7-isopropyl-10-methyl-1,5-dioxa-spiro[5.5]undec-3-en-2-one

Guidance literature:: Multi-step reaction with 9 steps

1: 96 percent / Red-Al / toluene

2: 98 percent / imidazole

3: 98 percent / H₂ / Pd-black / ethanol

4: 92 percent / Swern oxidation

5: 84 percent / MgBr₂*OEt₂ / diethyl ether

6: 1) t-BuLi, HMPA / 1) THF, -78 deg C

7: 92 percent / PPTS / methanol

8: 91 percent / SO₃*pyridine, DMSO, NEt₃

9: 1) LDA, 2) LiI

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; pyridine-SO₃ complex; hydrogen; tert.-butyl lithium; pyridinium p-toluenesulfonate; dimethyl sulfoxide; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; magnesium bromide; lithium iodide; lithium diisopropyl amide; palladium; In methanol; diethyl ether; ethanol; toluene;
DOI:10.1016/S0040-4039(00)74063-9

Reference yield:

: 152426-81-8
(3S)-1-benzyloxy-2,2-dimethylpentane-3,5-diol

: 297135-61-6
(6R,7S,10R)-4-[(2S,4S)-5-[2-((2S,6R)-6-Benzyloxymethyl-4,4-dimethoxy-tetrahydro-pyran-2-ylmethyl)-[1,3]dithian-2-yl]-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-5-methyl-hexyl]-7-isopropyl-10-methyl-1,5-dioxa-spiro[5.5]undec-3-en-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / imidazole

2: 98 percent / H₂ / Pd-black / ethanol

3: 92 percent / Swern oxidation

4: 84 percent / MgBr₂*OEt₂ / diethyl ether

5: 1) t-BuLi, HMPA / 1) THF, -78 deg C

6: 92 percent / PPTS / methanol

7: 91 percent / SO₃*pyridine, DMSO, NEt₃

8: 1) LDA, 2) LiI

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; pyridine-SO₃ complex; hydrogen; tert.-butyl lithium; pyridinium p-toluenesulfonate; dimethyl sulfoxide; triethylamine; magnesium bromide; lithium iodide; lithium diisopropyl amide; palladium; In methanol; diethyl ether; ethanol;
DOI:10.1016/S0040-4039(00)74063-9

Reference yield:

: 187527-29-3
[(S)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-pentyloxymethyl]-benzene

: 297135-61-6
(6R,7S,10R)-4-[(2S,4S)-5-[2-((2S,6R)-6-Benzyloxymethyl-4,4-dimethoxy-tetrahydro-pyran-2-ylmethyl)-[1,3]dithian-2-yl]-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-5-methyl-hexyl]-7-isopropyl-10-methyl-1,5-dioxa-spiro[5.5]undec-3-en-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / H₂ / Pd-black / ethanol

2: 92 percent / Swern oxidation

3: 84 percent / MgBr₂*OEt₂ / diethyl ether

4: 1) t-BuLi, HMPA / 1) THF, -78 deg C

5: 92 percent / PPTS / methanol

6: 91 percent / SO₃*pyridine, DMSO, NEt₃

7: 1) LDA, 2) LiI

With N,N,N,N,N,N-hexamethylphosphoric triamide; pyridine-SO₃ complex; hydrogen; tert.-butyl lithium; pyridinium p-toluenesulfonate; dimethyl sulfoxide; triethylamine; magnesium bromide; lithium iodide; lithium diisopropyl amide; palladium; In methanol; diethyl ether; ethanol;
DOI:10.1016/S0040-4039(00)74063-9