2-{4-[2-(tert-butyldiphenylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-7-fluoro-5-methoxy-3H-quinazolin-4-one

Base Information

Chemical Name:2-{4-[2-(tert-butyldiphenylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-7-fluoro-5-methoxy-3H-quinazolin-4-one
CAS No.:1253732-48-7
Molecular Formula:C₃₅H₃₇FN₂O₄Si
Molecular Weight:596.774
Hs Code.:

Synonyms:2-{4-[2-(tert-butyldiphenylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-7-fluoro-5-methoxy-3H-quinazolin-4-one

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Chemical Property of 2-{4-[2-(tert-butyldiphenylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-7-fluoro-5-methoxy-3H-quinazolin-4-one

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Technology Process of 2-{4-[2-(tert-butyldiphenylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-7-fluoro-5-methoxy-3H-quinazolin-4-one

There total 7 articles about 2-{4-[2-(tert-butyldiphenylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-7-fluoro-5-methoxy-3H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1253732-46-5
7-fluoro-2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5-methoxy-3H-quinazolin-4-one

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1253732-48-7
2-{4-[2-(tert-butyldiphenylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-7-fluoro-5-methoxy-3H-quinazolin-4-one

Guidance literature:: With 1H-imidazole; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 893428-66-5
2-amino-4,6-difluoro-benzamide

: 1253732-48-7
2-{4-[2-(tert-butyldiphenylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-7-fluoro-5-methoxy-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogen sulfate; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 14 h / 155 °C

2: sodium methylate / N,N-dimethyl-formamide / 16 h / 20 °C

3: 1H-imidazole / tetrahydrofuran / 16 h / 20 °C

With 1H-imidazole; sodium hydrogen sulfate; sodium methylate; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 126674-77-9
2-amino-4,6-difluorobenzoic acid

: 1253732-48-7
2-{4-[2-(tert-butyldiphenylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-7-fluoro-5-methoxy-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 1 h / 20 °C

1.2: 6 h / 20 °C

2.1: sodium hydrogen sulfate; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 14 h / 155 °C

3.1: sodium methylate / N,N-dimethyl-formamide / 16 h / 20 °C

4.1: 1H-imidazole / tetrahydrofuran / 16 h / 20 °C

With 1H-imidazole; sodium hydrogen sulfate; sodium methylate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl acetamide; N,N-dimethyl-formamide;