7-(2-benzyloxy-ethoxy)-2-[4-(2-hydroxy-ethoxy)-3,5-dimethyl-phenyl]-5-methoxy-3H-quinazolin-4-one

Base Information

Chemical Name:7-(2-benzyloxy-ethoxy)-2-[4-(2-hydroxy-ethoxy)-3,5-dimethyl-phenyl]-5-methoxy-3H-quinazolin-4-one
CAS No.:1253732-42-1
Molecular Formula:C₂₈H₃₀N₂O₆
Molecular Weight:490.556
Hs Code.:

Synonyms:7-(2-benzyloxy-ethoxy)-2-[4-(2-hydroxy-ethoxy)-3,5-dimethyl-phenyl]-5-methoxy-3H-quinazolin-4-one

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Chemical Property of 7-(2-benzyloxy-ethoxy)-2-[4-(2-hydroxy-ethoxy)-3,5-dimethyl-phenyl]-5-methoxy-3H-quinazolin-4-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 7-(2-benzyloxy-ethoxy)-2-[4-(2-hydroxy-ethoxy)-3,5-dimethyl-phenyl]-5-methoxy-3H-quinazolin-4-one

There total 8 articles about 7-(2-benzyloxy-ethoxy)-2-[4-(2-hydroxy-ethoxy)-3,5-dimethyl-phenyl]-5-methoxy-3H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 622-08-2,1201808-31-2
2-Benzyloxyethanol

: 1253732-48-7
2-{4-[2-(tert-butyldiphenylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-7-fluoro-5-methoxy-3H-quinazolin-4-one

: 1253732-42-1
7-(2-benzyloxy-ethoxy)-2-[4-(2-hydroxy-ethoxy)-3,5-dimethyl-phenyl]-5-methoxy-3H-quinazolin-4-one

Guidance literature:: 2-Benzyloxyethanol; With sodium hydride; In dimethyl sulfoxide; at 20 ℃;

2-{4-[2-(tert-butyldiphenylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-7-fluoro-5-methoxy-3H-quinazolin-4-one; In dimethyl sulfoxide; at 70 ℃; for 16h;

With acetic acid; In water; pH=4 - 5;

Reference yield:

: 893428-66-5
2-amino-4,6-difluoro-benzamide

: 1253732-42-1
7-(2-benzyloxy-ethoxy)-2-[4-(2-hydroxy-ethoxy)-3,5-dimethyl-phenyl]-5-methoxy-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogen sulfate; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 14 h / 155 °C

2.1: sodium methylate / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: 1H-imidazole / tetrahydrofuran / 16 h / 20 °C

4.1: sodium hydride / dimethyl sulfoxide / 0.75 h / 20 °C

4.2: 16 h / 70 °C

With 1H-imidazole; sodium hydrogen sulfate; sodium methylate; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl acetamide; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 134-96-3
syringic aldehyde

: 1253732-42-1
7-(2-benzyloxy-ethoxy)-2-[4-(2-hydroxy-ethoxy)-3,5-dimethyl-phenyl]-5-methoxy-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride; potassium iodide / N,N-dimethyl-formamide / 14 h / 70 °C

2.1: sodium hydrogen sulfate; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 14 h / 155 °C

3.1: sodium methylate / N,N-dimethyl-formamide / 16 h / 20 °C

4.1: 1H-imidazole / tetrahydrofuran / 16 h / 20 °C

5.1: sodium hydride / dimethyl sulfoxide / 0.75 h / 20 °C

5.2: 16 h / 70 °C

With 1H-imidazole; sodium hydrogen sulfate; sodium methylate; sodium hydride; toluene-4-sulfonic acid; potassium iodide; In tetrahydrofuran; N,N-dimethyl acetamide; dimethyl sulfoxide; N,N-dimethyl-formamide;