ALPHA-METHYL-DL-SERINE

Base Information

• Chemical Name: ALPHA-METHYL-DL-SERINE
• CAS No.: 3398-40-1
• Molecular Formula: C₄H₉NO₃
• Molecular Weight: 119.12
• Hs Code.: 2922509090
• Mol file: 3398-40-1.mol

Synonyms:A-METHYL-D,L-SERINE;DL-2-METHYLSERINE;DL-A-METHYLSERINE;2-methyl-serin;Serine,2-methyl.;2-amino-3-hydroxy-2-methylpropanoic acid;

Chemical Property of ALPHA-METHYL-DL-SERINE

Chemical Property:

• Melting Point: 253-263°C
• PSA: 83.55000
• LogP: -0.51900

Purity/Quality:

99% ^*data from raw suppliers

a-Methyl-D,L-serine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ALPHA-METHYL-DL-SERINE

There total 46 articles about ALPHA-METHYL-DL-SERINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(2R,4S)-methyl 2-tert-butyl-3-formyl-4-methyloxazolidine-4-carboxylate (93250-94-3) → (S)-(+)-2-amino-2-methyl-3-hydroxypropanoic acid (3398-40-1,5424-29-3,16820-18-1,81132-44-7)

Guidance literature:

With hydrogenchloride; at 120 ℃; for 1.5h; freeing from salt with Dowex W₅₀*X₈;

DOI:10.1002/hlca.19870700426

Reference yield: 93.0%

((R)-1-Cyano-2-methoxymethoxy-1-methyl-ethyl)-carbamic acid methyl ester → (S)-(+)-2-amino-2-methyl-3-hydroxypropanoic acid (3398-40-1,5424-29-3,16820-18-1,81132-44-7)

Guidance literature:

With hydrogenchloride; for 12h; Heating;

DOI:10.1016/S0040-4020(98)00937-5

Reference yield: 92.0%

(1R,4S,7R,8S)-1,4,11,11-tetramethyl-4-(hydroxymethyl)-6-oxa-3-aza-tricyclo[6.2.1.02,7]undec-2-en-5-one (1059607-17-8) → (S)-(+)-2-amino-2-methyl-3-hydroxypropanoic acid (3398-40-1,5424-29-3,16820-18-1,81132-44-7)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 90 ℃; for 4h;

DOI:10.1016/j.tetasy.2008.06.033

upstream raw materials:

5-hydroxymethyl-5-methyl-imidazolidine-2,4-dione

formaldehyd

L-alanin

(S)-N-(2-benzoylphenyl)-1-benzylpyrrolidine-2-carboxamide

Downstream raw materials:

(S)-2-tert-Butoxycarbonylamino-3-hydroxy-2-methyl-propionic acid

(R)-2-N-(tert-butoxycarbonyl)amino-2-methyl-3-hydroxy-propanoic acid

(S)-2-N-(tert-butoxycarbonyl)amino-2-methyl-3-hydroxypropanoic acid methyl ester

(R)-2-N-(tert-butoxycarbonyl)amino-2-methyl-3-hydroxypropanoic acid methyl ester