2-(dimethylamino-methyleneamino)-3,6-dimethoxy-benzoic acid methylester

Base Information

• Chemical Name: 2-(dimethylamino-methyleneamino)-3,6-dimethoxy-benzoic acid methylester
• CAS No.: 214476-65-0
• Molecular Formula: C₁₃H₁₈N₂O₄
• Molecular Weight: 266.297
• Mol file: 214476-65-0.mol

Synonyms:2-(dimethylamino-methyleneamino)-3,6-dimethoxy-benzoic acid methylester

Chemical Property of 2-(dimethylamino-methyleneamino)-3,6-dimethoxy-benzoic acid methylester

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of 2-(dimethylamino-methyleneamino)-3,6-dimethoxy-benzoic acid methylester

There total 2 articles about 2-(dimethylamino-methyleneamino)-3,6-dimethoxy-benzoic acid methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-3,6-dimethoxybenzoic acid (50472-10-1) → 2-(dimethylamino-methyleneamino)-3,6-dimethoxy-benzoic acid methylester (214476-65-0)

Guidance literature:

In ethyl acetate;

Reference yield:

2-amino-3,6-dimethoxybenzoic acid (50472-10-1) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 2-(dimethylamino-methyleneamino)-3,6-dimethoxy-benzoic acid methylester (214476-65-0)

Guidance literature:

for 18h; Heating / reflux;

Reference yield:

2-(dimethylamino-methyleneamino)-3,6-dimethoxy-benzoic acid methylester (214476-65-0) → 4-(3-Bromo-phenylamino)-5.8-dimethoxy-quinoline-3-carbonitrile

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C

1.2: 0.42 h / -78 - 20 °C

2.1: trichlorophosphate / N,N-dimethyl-formamide / 0.17 h / Heating / reflux

3.1: 2-ethoxy-ethanol / 0.5 h / Heating / reflux

3.2: pH 9

With n-butyllithium; trichlorophosphate; N,N-dimethyl-formamide; In tetrahydrofuran; 2-ethoxy-ethanol; hexane;

upstream raw materials:

2-amino-3,6-dimethoxybenzoic acid

N,N-dimethyl-formamide dimethyl acetal

Downstream raw materials:

4-Hydroxy-5.8-dimethoxy-quinoline-3-carbonitrile

4-chloro-5,8-dimethoxy-quinoline-3-carbonitrile