thiophen-2-yl(4-(2-(2,4-dichlorophenoxy)ethyl)piperazin-1-yl)methanone

Base Information

Chemical Name:thiophen-2-yl(4-(2-(2,4-dichlorophenoxy)ethyl)piperazin-1-yl)methanone
CAS No.:1352792-24-5
Molecular Formula:C₁₇H₁₈Cl₂N₂O₂S
Molecular Weight:385.314
Hs Code.:

Synonyms:thiophen-2-yl(4-(2-(2,4-dichlorophenoxy)ethyl)piperazin-1-yl)methanone

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Chemical Property of thiophen-2-yl(4-(2-(2,4-dichlorophenoxy)ethyl)piperazin-1-yl)methanone

Chemical Property:

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Technology Process of thiophen-2-yl(4-(2-(2,4-dichlorophenoxy)ethyl)piperazin-1-yl)methanone

There total 4 articles about thiophen-2-yl(4-(2-(2,4-dichlorophenoxy)ethyl)piperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.52%

: 5271-67-0
2-Thiophenecarbonyl chloride

: 401509-33-9
C₁₂H₁₆Cl₂N₂O

: 1352792-24-5
thiophen-2-yl(4-(2-(2,4-dichlorophenoxy)ethyl)piperazin-1-yl)methanone

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 8h;
DOI:10.1016/j.ejmech.2014.03.075

Reference yield:

: 120-83-2,40477-79-0
2,4-dichlorophenol

: 1352792-24-5
thiophen-2-yl(4-(2-(2,4-dichlorophenoxy)ethyl)piperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 24 h / 50 °C / Reflux

2: hydrogen bromide / water; ethanol / 48 h / 20 °C / Reflux

3: triethylamine / dichloromethane / 8 h / 0 - 20 °C

With hydrogen bromide; potassium carbonate; triethylamine; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.ejmech.2014.03.075

Reference yield:

: 527-72-0
2-thiophenylcarboxylic acid

: 1352792-24-5
thiophen-2-yl(4-(2-(2,4-dichlorophenoxy)ethyl)piperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 4 h / Reflux

2: triethylamine / dichloromethane / 8 h / 0 - 20 °C

With thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1016/j.ejmech.2014.03.075