2,4-Dichlorophenol

Base Information

• Chemical Name: 2,4-Dichlorophenol
• CAS No.: 120-83-2
• Molecular Formula: C6H4Cl2O
• Molecular Weight: 163.003
• Hs Code.: 2908.10
• European Community (EC) Number: 204-429-6
• ICSC Number: 0438
• NSC Number: 2879
• UN Number: 2020
• UNII: R669TG1950
• DSSTox Substance ID: DTXSID1020439
• Nikkaji Number: J2.005B
• Wikipedia: 2,4-Dichlorophenol
• Wikidata: Q209205
• Metabolomics Workbench ID: 38547
• ChEMBL ID: CHEMBL1143
• Mol file: 120-83-2.mol

Synonyms:2,4-dichlorophenol;2,4-dichlorophenol potassium;2,4-dichlorophenol sodium;2,4-dichlorophenol, 14C-labeled cpd;4,6-dichlorophenol

Chemical Property of 2,4-Dichlorophenol

Chemical Property:

• Appearance/Colour: white to off-white crystalline solid
• Vapor Pressure: 0.136mmHg at 25°C
• Melting Point: 42-43 °C(lit.)
• Boiling Point: 85.7 °C at 760 mmHg
• Flash Point: 10.5 °C
• PSA: 20.23000
• Density: 1.383 g/cm³
• LogP: 2.69900
• Water Solubility.: 4.5 g/L (20℃)
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 161.9639201
• Heavy Atom Count: 9
• Complexity: 97.1
• Transport DOT Label: Poison

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s): T,N,F
• Hazard Codes: T:Toxic;;
• Statements: R22:; R24:; R34:; R51/53:
• Safety Statements: S26:; S36/37/39:; S45:; S61:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Chlorophenols
• Canonical SMILES: C1=CC(=C(C=C1Cl)Cl)O
• Inhalation Risk: A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C; when in molten form, however, evaporation will be much faster.
• Effects of Short Term Exposure: The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. The hot liquid may cause severe skin burns. Exposure to the molten substance may result in extensive skin absorption and rapid death. Inhalation of the vapour may cause lung oedema. Medical observation is indicated. The substance may cause effects on the central nervous system.
• General Description: 2,4-Dichlorophenol (2,4-DCP) is a chlorinated phenolic compound recognized as a hazardous environmental pollutant. Enzymatic degradation using horseradish peroxidase (HRP) immobilized on superparamagnetic Fe₃O₄/graphene oxide nanocomposites has been shown to effectively remove 2,4-DCP, along with other chlorophenols, from wastewater. The immobilized HRP system offers enhanced stability, pH and temperature tolerance, and reusability due to magnetic recovery, making it a promising solution for the treatment of chlorophenol-contaminated water.

Technology Process of 2,4-Dichlorophenol

There total 151 articles about 2,4-Dichlorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-chloro-phenol (106-48-9,82344-39-6) → 2,4-dichlorophenol (120-83-2,40477-79-0) + 2,4,6-Trichlorophenol (88-06-2,67471-29-8)

Guidance literature:

With hydrogenchloride; 3-chloro-benzenecarboperoxoic acid; In N,N-dimethyl-formamide; for 0.333333h; Product distribution; Ambient temperature; other phenols;

Reference yield: 18.4%

phenol (108-95-2,27073-41-2) → 2,6-Dichlorophenol (87-65-0) + 2-monochlorophenol (95-57-8) + 4-chloro-phenol (106-48-9,82344-39-6) + 2,4-dichlorophenol (120-83-2,40477-79-0) + 2,4,6-Trichlorophenol (88-06-2,67471-29-8)

Guidance literature:

With aluminium trichloride; diphenyl sulfide; chlorine; In neat (no solvent); at 35 ℃; for 1.5h; Product distribution; others 2-alkylphenols; var. chlorinating agent, temp., and time;

DOI:10.1021/jo00212a029

Reference yield: 6.0%

phenol (108-95-2,27073-41-2) → 2,4-dichlorophenol (120-83-2,40477-79-0) + 2,4,6-Trichlorophenol (88-06-2,67471-29-8)

Guidance literature:

With hydrogenchloride; sodium chlorate; In water; acetic acid; at 20 ℃; for 26h;

DOI:10.5012/bkcs.2011.32.2.472

upstream raw materials:

1-bromo-2,4-dichlorobenzene

sodium methylate

ethanol

2,4-dichlorophenoxymethyl chloride

Downstream raw materials:

2-(2,4-dichlorophenoxy)ethanol

2-[2-(2,4-dichloro-phenoxy)-ethoxy]-ethanol

2,4-dichloro-6-piperidinomethyl-phenol

1-hydroxy-2,4-dichloro-9,10-anthraquinone

Refernces

Enzymatic removal of chlorophenols using horseradish peroxidase immobilized on superparamagnetic Fe₃O₄/graphene oxide nanocomposite

10.1016/S1872-2067(15)60856-7

This research aimed to develop an efficient method for the enzymatic removal of chlorophenols, which are harmful environmental pollutants, using horseradish peroxidase (HRP) immobilized on superparamagnetic Fe3O4/graphene oxide nanocomposites. The purpose was to leverage the high specificity and selectivity of enzymatic degradation while overcoming the poor stability and recovery challenges associated with free HRP. The study synthesized magnetic Fe3O4 nanoparticles deposited on graphene oxide sheets and used them to immobilize HRP. The immobilized HRP was then employed to remove 2-chlorophenol, 4-chlorophenol, and 2,4-dichlorophenol. The research concluded that the immobilized HRP demonstrated high stability, improved storage stability, and tolerance to pH and temperature changes compared to free HRP. It was also recoverable using an external magnetic field and retained significant activity over multiple cycles, showing potential for wastewater treatment applications.