DIETHYL MALONIMIDATE DIHYDROCHLORIDE

Base Information

• Chemical Name: DIETHYL MALONIMIDATE DIHYDROCHLORIDE
• CAS No.: 10344-69-1
• Molecular Formula: C7H14 N2 O2 . 2 Cl H
• Molecular Weight: 231.122
• Hs Code.: 2925199590
• Mol file: 10344-69-1.mol

Synonyms:Malonimidicacid, diethyl ester, dihydrochloride (7CI,8CI); Propanediimidic acid, diethyl ester,dihydrochloride (9CI); Diethyl malonimidate dihydrochloride

Chemical Property of DIETHYL MALONIMIDATE DIHYDROCHLORIDE

Chemical Property:

• Appearance/Colour: WHITE TO YELLOW POWDER OR CRYSTALLINE POWDER
• Vapor Pressure: 0.688mmHg at 25°C
• Melting Point: 122 °C (dec.)(lit.)
• Refractive Index: 1.444
• Boiling Point: 171.8 °C at 760 mmHg
• Flash Point: 57.7 °C
• PSA: 66.16000
• Density: g/cm³
• LogP: 3.20750
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Diethyl malonimidate dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Reactant for:Preparation of rhenium cyanobis(oxazoline) oxo complexes as enantioselective reduction catalystsSynthesis of chiral bis(oxazoline)-copper complexes immobilized by donor-acceptor interactions on insoluble organic supports as reusable catalysts for asymmetric Diels-Alder cycloadditionPreparation of nonracemic bis(oxazoline)ruthenium p-cymene complexes and silica-supported analogs as catalysts for the enantioselective transfer hydrogenation of ketones to secondary alcohols

Technology Process of DIETHYL MALONIMIDATE DIHYDROCHLORIDE

There total 1 articles about DIETHYL MALONIMIDATE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + malononitrile (109-77-3) → diethyl malonoimidate dihydrochloride (10344-69-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 24h;

DOI:10.1039/c1dt10732a

Reference yield: 98.0%

(R,R)-1,2-diphenylethylenediamine (35132-20-8) + diethyl malonoimidate dihydrochloride (10344-69-1) → (R,R,R,R)-2,2'-methylenedi(4,5-diphenyl-4,5-dihydro-1H-imidazole)

Guidance literature:

In ethanol; at 65 ℃; for 12h;

DOI:10.1021/acs.orglett.8b02374

Reference yield: 92.0%

(R,R)-1,2-diphenylethylenediamine (35132-20-8) + diethyl malonoimidate dihydrochloride (10344-69-1) → CH2(CN2H2C2HC12H10)2*HCl

Guidance literature:

In ethanol; at 75 ℃; for 16h;

DOI:10.1021/jo070534j

upstream raw materials:

ethanol

malononitrile

Downstream raw materials:

ethyl malonamate

ethyl 2-cyanoacetimidate

diethyl malonate

chloroethane

Refernces

• 1、 Brown, R.S.,Clewley, R.G. "Intramolecular Imidazole-Promoted General-Base Catalysis of the Hydrolysis of an Acetylimidazole". . p. 1216 - 1218. Retrieved 1987.
• 2、 Novosád, David,Styskala, Jakub. "Analogs of biologically active compounds IX.1 Synthesis of several new uracil and pteridine 6-azaanalogs based on cyclization of arylhydrazones derived from mesoxalic acid". . p. 129 - 140. Retrieved 2017.
• 3、 Han, Xue,Shan, Li-Xin,Zhu, Jin-Xin,Zhang, Chang-Sheng,Zhang, Xiao-Ming,Zhang, Fu-Min,Wang, Hong,Tu, Yong-Qiang,Yang, Ming,Zhang, Wen-Shuo. "Copper-Nitrene-Catalyzed Desymmetric Oxaziridination/1,2-Alkyl Rearrangement of 1,3-Diketones toward Bicyclic Lactams". supporting information. p. 22688 - 22692. Retrieved 2021/09/18.