(S)-2-(7-benzyloxycarbamoyl-heptanoylamino)-3-methyl-butyric acid methyl ester

Base Information

• Chemical Name: (S)-2-(7-benzyloxycarbamoyl-heptanoylamino)-3-methyl-butyric acid methyl ester
• CAS No.: 449728-96-5
• Molecular Formula: C₂₁H₃₂N₂O₅
• Molecular Weight: 392.495
• Mol file: 449728-96-5.mol

Synonyms:(S)-2-(7-benzyloxycarbamoyl-heptanoylamino)-3-methyl-butyric acid methyl ester

Chemical Property of (S)-2-(7-benzyloxycarbamoyl-heptanoylamino)-3-methyl-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(7-benzyloxycarbamoyl-heptanoylamino)-3-methyl-butyric acid methyl ester

There total 4 articles about (S)-2-(7-benzyloxycarbamoyl-heptanoylamino)-3-methyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

L-valine methylester hydrochloride (6306-52-1) + 8-((benzyloxy)amino)-8-oxooctanoic acid (251304-81-1) → (S)-2-(7-benzyloxycarbamoyl-heptanoylamino)-3-methyl-butyric acid methyl ester (449728-96-5)

Guidance literature:

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1021/jm0208119

Reference yield:

suberic acid monomethyl ester (3946-32-5) → (S)-2-(7-benzyloxycarbamoyl-heptanoylamino)-3-methyl-butyric acid methyl ester (449728-96-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / iPr₂NEt; BOP-Cl / CH₂Cl₂

2: 68 percent / aq. LiOH / tetrahydrofuran / 20 °C

3: 64 percent / iPr₂NEt; BOP-Cl / CH₂Cl₂

With lithium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm0208119

Reference yield:

O-benzylhydoxylamine hydrochloride (2687-43-6) → (S)-2-(7-benzyloxycarbamoyl-heptanoylamino)-3-methyl-butyric acid methyl ester (449728-96-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / iPr₂NEt; BOP-Cl / CH₂Cl₂

2: 68 percent / aq. LiOH / tetrahydrofuran / 20 °C

3: 64 percent / iPr₂NEt; BOP-Cl / CH₂Cl₂

With lithium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm0208119

upstream raw materials:

L-valine methylester hydrochloride

8-((benzyloxy)amino)-8-oxooctanoic acid

suberic acid monomethyl ester

O-benzylhydoxylamine hydrochloride