tert-butyl [(2R)-1-(4-bromophenyl)-3-oxypropan-2-yl] carbamate

Base Information

• Chemical Name: tert-butyl [(2R)-1-(4-bromophenyl)-3-oxypropan-2-yl] carbamate
• CAS No.: 1246363-08-5
• Molecular Formula: C₁₄H₁₈BrNO₃
• Molecular Weight: 328.206
• Mol file: 1246363-08-5.mol

Synonyms:tert-butyl [(2R)-1-(4-bromophenyl)-3-oxypropan-2-yl] carbamate

Chemical Property of tert-butyl [(2R)-1-(4-bromophenyl)-3-oxypropan-2-yl] carbamate

Chemical Property:

Purity/Quality:

98% HPLC ^*data from raw suppliers

(R)-tert-Butyl(1-(4-bromophenyl)-3-oxopropan-2-yl)carbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl [(2R)-1-(4-bromophenyl)-3-oxypropan-2-yl] carbamate

There total 5 articles about tert-butyl [(2R)-1-(4-bromophenyl)-3-oxypropan-2-yl] carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (R)-3-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate (1213855-60-7) → tert-butyl [(2R)-1-(4-bromophenyl)-3-oxypropan-2-yl] carbamate (1246363-08-5)

Guidance literature:

methyl (R)-3-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate; With diisobutylaluminium hydride; In dichloromethane; at -78 ℃;

With ethyl acetate;

Reference yield:

tert-butyl [(2R)-1-(4-bromophenyl)-3-hydroxypropan-2-yl] carbamate → tert-butyl [(2R)-1-(4-bromophenyl)-3-oxypropan-2-yl] carbamate (1246363-08-5)

Guidance literature:

With sodium hypochlorite solution; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide; In water; ethyl acetate; for 2h;

Reference yield:

(2R)-3-(4-bromophenyl)-2-[[(tert-butoxy)carbonyl]amino]propanoic acid (79561-82-3) → tert-butyl [(2R)-1-(4-bromophenyl)-3-oxypropan-2-yl] carbamate (1246363-08-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 4 h / 25 - 35 °C

2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide; sodium hypochlorite solution / ethyl acetate; water / 2 h

With sodium tetrahydroborate; sodium hypochlorite solution; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide; In ethanol; water; ethyl acetate;

upstream raw materials:

methyl (R)-3-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate

(2R)-3-(4-bromophenyl)-2-[[(tert-butoxy)carbonyl]amino]propanoic acid

(2R)-2-amino-3-(4-bromophenyl)propanoic acid

di-tert-butyl dicarbonate

Downstream raw materials:

ethyl (2E, 4R)-5-(4-bromophenyl)-4-[(tert-butoxycarbonyl) amino]-2-methylpent-enoate

α-ethyl (αR,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride