ethyl (2E, 4R)-5-(4-bromophenyl)-4-[(tert-butoxycarbonyl) amino]-2-methylpent-enoate

Base Information

Chemical Name:ethyl (2E, 4R)-5-(4-bromophenyl)-4-[(tert-butoxycarbonyl) amino]-2-methylpent-enoate
CAS No.:1257266-88-8
Molecular Formula:C₁₉H₂₆BrNO₄
Molecular Weight:412.324
Hs Code.:

Synonyms:ethyl (2E, 4R)-5-(4-bromophenyl)-4-[(tert-butoxycarbonyl) amino]-2-methylpent-enoate

Suppliers and Price of ethyl (2E, 4R)-5-(4-bromophenyl)-4-[(tert-butoxycarbonyl) amino]-2-methylpent-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (2E, 4R)-5-(4-bromophenyl)-4-[(tert-butoxycarbonyl) amino]-2-methylpent-enoate

Chemical Property:

Purity/Quality:: 98% HPLC ^*data from raw suppliers

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Technology Process of ethyl (2E, 4R)-5-(4-bromophenyl)-4-[(tert-butoxycarbonyl) amino]-2-methylpent-enoate

There total 4 articles about ethyl (2E, 4R)-5-(4-bromophenyl)-4-[(tert-butoxycarbonyl) amino]-2-methylpent-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246363-08-5
tert-butyl [(2R)-1-(4-bromophenyl)-3-oxypropan-2-yl] carbamate

: 21382-82-1
(carbethoxyethylidene)triphenylphosphorane

: 1257266-88-8
ethyl (2E, 4R)-5-(4-bromophenyl)-4-[(tert-butoxycarbonyl) amino]-2-methylpent-enoate

Guidance literature:: In dichloromethane; at 20 ℃;

Reference yield:

: 79561-82-3
(2R)-3-(4-bromophenyl)-2-[[(tert-butoxy)carbonyl]amino]propanoic acid

: 1257266-88-8
ethyl (2E, 4R)-5-(4-bromophenyl)-4-[(tert-butoxycarbonyl) amino]-2-methylpent-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / ethanol / 4 h / 25 - 35 °C

2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide; sodium hypochlorite solution / ethyl acetate; water / 2 h

3: ethyl acetate / 2 h / 25 - 35 °C

With sodium tetrahydroborate; sodium hypochlorite solution; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide; In ethanol; water; ethyl acetate; 3: |Wittig Olefination;

Reference yield:

: 62561-74-4
(2R)-2-amino-3-(4-bromophenyl)propanoic acid

: 1257266-88-8
ethyl (2E, 4R)-5-(4-bromophenyl)-4-[(tert-butoxycarbonyl) amino]-2-methylpent-enoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: thiophosgene / methanol / 4 h / 60 - 65 °C

1.2: 6 h / 25 - 35 °C

2.1: sodium tetrahydroborate / ethanol / 4 h / 25 - 35 °C

3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide; sodium hypochlorite solution / ethyl acetate; water / 2 h

4.1: ethyl acetate / 2 h / 25 - 35 °C

With sodium tetrahydroborate; sodium hypochlorite solution; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; thiophosgene; sodium hydrogencarbonate; sodium bromide; In methanol; ethanol; water; ethyl acetate; 4.1: |Wittig Olefination;