(4-fluoro-3-methoxyphenyl)(3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl)methanone

Base Information

Chemical Name:(4-fluoro-3-methoxyphenyl)(3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl)methanone
CAS No.:939039-46-0
Molecular Formula:C₁₆H₁₀F₆O₃
Molecular Weight:364.244
Hs Code.:

Synonyms:(4-fluoro-3-methoxyphenyl)(3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl)methanone

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Chemical Property of (4-fluoro-3-methoxyphenyl)(3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl)methanone

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Technology Process of (4-fluoro-3-methoxyphenyl)(3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl)methanone

There total 3 articles about (4-fluoro-3-methoxyphenyl)(3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1-bromo-3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)benzene

: 243128-37-2
4-fluoro-3-methoxybenzonitrile

: 939039-46-0
(4-fluoro-3-methoxyphenyl)(3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl)methanone

Guidance literature:: 1-bromo-3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)benzene; With n-butyllithium; In diethyl ether; at -75 - -60 ℃;

4-fluoro-3-methoxybenzonitrile; In tetrahydrofuran; diethyl ether;

With water; In tetrahydrofuran; diethyl ether;

Reference yield:

: 461-96-1
3,5-difluorobromobenzene

: 939039-46-0
(4-fluoro-3-methoxyphenyl)(3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium trimethylsilonate / diethylene glycol dimethyl ether / 5 h / 120 °C / Inert atmosphere

2.1: caesium carbonate / dimethyl sulfoxide / 5 h / 50 °C / Inert atmosphere

2.2: 1 h / 50 °C / Inert atmosphere

3.1: n-butyllithium / hexane; diethyl ether / 0.75 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 °C / Inert atmosphere

With n-butyllithium; potassium trimethylsilonate; caesium carbonate; In diethyl ether; hexane; diethylene glycol dimethyl ether; dimethyl sulfoxide;
DOI:10.1021/acs.jmedchem.5b01363

Reference yield:

: 433939-27-6
3-bromo-5-fluorophenol

: 939039-46-0
(4-fluoro-3-methoxyphenyl)(3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / dimethyl sulfoxide / 5 h / 50 °C / Inert atmosphere

1.2: 1 h / 50 °C / Inert atmosphere

2.1: n-butyllithium / hexane; diethyl ether / 0.75 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C / Inert atmosphere

With n-butyllithium; caesium carbonate; In diethyl ether; hexane; dimethyl sulfoxide;
DOI:10.1021/acs.jmedchem.5b01363