(S)-3,5-dichloro-4-(2-((3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzyloxy)carbonyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

Base Information

• Chemical Name: (S)-3,5-dichloro-4-(2-((3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzyloxy)carbonyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide
• CAS No.: 1428848-43-4
• Molecular Formula: C₃₁H₂₉Cl₂F₄NO₈
• Molecular Weight: 690.473
• Mol file: 1428848-43-4.mol

Synonyms:(S)-3,5-dichloro-4-(2-((3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzyloxy)carbonyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

Chemical Property of (S)-3,5-dichloro-4-(2-((3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzyloxy)carbonyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3,5-dichloro-4-(2-((3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzyloxy)carbonyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

There total 5 articles about (S)-3,5-dichloro-4-(2-((3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzyloxy)carbonyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.8%

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((4-nitrophenoxy)carbonyloxy)-ethyl)pyridine 1-oxide (1428846-77-8) + (3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-methanol (151450-20-3) → (S)-3,5-dichloro-4-(2-((3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzyloxy)carbonyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide (1428848-43-4)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

4-difluoromethoxy-3-hydroxybenzaldehyde (151103-08-1) → (S)-3,5-dichloro-4-(2-((3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzyloxy)carbonyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide (1428848-43-4)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 24 h / 20 °C

2: potassium permanganate; potassium carbonate / water; acetone / 1 h / 60 °C

3: borane-THF / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

4: dmap / dichloromethane / 4 h / 20 °C

With dmap; potassium permanganate; borane-THF; potassium carbonate; potassium iodide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde (151103-09-2) → (S)-3,5-dichloro-4-(2-((3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzyloxy)carbonyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide (1428848-43-4)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium permanganate; potassium carbonate / water; acetone / 1 h / 60 °C

2: borane-THF / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

3: dmap / dichloromethane / 4 h / 20 °C

With dmap; potassium permanganate; borane-THF; potassium carbonate; In tetrahydrofuran; dichloromethane; water; acetone;

upstream raw materials:

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((4-nitrophenoxy)carbonyloxy)-ethyl)pyridine 1-oxide

(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-methanol

4-difluoromethoxy-3-hydroxybenzaldehyde

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde