(3-(cyclopropylMethoxy)-4-(difluoroMethoxy)phenyl)Methanol

Base Information

• Chemical Name: (3-(cyclopropylMethoxy)-4-(difluoroMethoxy)phenyl)Methanol
• CAS No.: 151450-20-3
• Molecular Formula: C₁₂H₁₄F₂O₃
• Molecular Weight: 244.238
• Mol file: 151450-20-3.mol

Synonyms:(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-methanol

Chemical Property of (3-(cyclopropylMethoxy)-4-(difluoroMethoxy)phenyl)Methanol

Chemical Property:

• Boiling Point: 334.3±37.0 °C(Predicted)
• PKA: 14.06±0.10(Predicted)
• Density: 1.273±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-(cyclopropylMethoxy)-4-(difluoroMethoxy)phenyl)Methanol

There total 3 articles about (3-(cyclopropylMethoxy)-4-(difluoroMethoxy)phenyl)Methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde (151103-09-2) → (3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-methanol (151450-20-3)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; water; at 0 ℃; for 0.166667h;

DOI:10.1016/j.ejmech.2017.09.077

Reference yield:

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid (162401-62-9) → (3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-methanol (151450-20-3)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

4-difluoromethoxy-3-hydroxybenzaldehyde (151103-08-1) → (3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-methanol (151450-20-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 24 h / 20 °C

2: potassium permanganate; potassium carbonate / water; acetone / 1 h / 60 °C

3: borane-THF / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With potassium permanganate; borane-THF; potassium carbonate; potassium iodide; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone;

upstream raw materials:

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

4-difluoromethoxy-3-hydroxybenzaldehyde

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

Downstream raw materials:

(S)-3,5-dichloro-4-(2-((3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzyloxy)carbonyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)acetonitrile

3-cyclopropylmethoxy-4-difluoromethoxybenzyl chloride