N-methoxy-N-methyl-4-[1-oxo-2-(2-pyrrolidin-1-ylethyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]benzamide

Base Information

Chemical Name:N-methoxy-N-methyl-4-[1-oxo-2-(2-pyrrolidin-1-ylethyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]benzamide
CAS No.:1131224-10-6
Molecular Formula:C₂₄H₂₉N₃O₃
Molecular Weight:407.513
Hs Code.:

Synonyms:N-methoxy-N-methyl-4-[1-oxo-2-(2-pyrrolidin-1-ylethyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-methoxy-N-methyl-4-[1-oxo-2-(2-pyrrolidin-1-ylethyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]benzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-methoxy-N-methyl-4-[1-oxo-2-(2-pyrrolidin-1-ylethyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]benzamide

There total 8 articles about N-methoxy-N-methyl-4-[1-oxo-2-(2-pyrrolidin-1-ylethyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147497-32-3
6-bromo-3,4-dihydroisoquinolin-1(2H)-one

: 1131224-10-6
N-methoxy-N-methyl-4-[1-oxo-2-(2-pyrrolidin-1-ylethyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.58 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: sodium periodate / tetrahydrofuran; water / 0.17 h / 0 °C

2.2: 8 h / 0 °C

3.1: sodium cyanoborohydride; acetic acid / methanol / 20 °C

4.1: dichlorobis(tri-O-tolylphosphine)palladium; potassium carbonate / 1,4-dioxane; water / 0.5 h / 90 °C

5.1: water; sodium hydroxide / ethanol / 3 h / 20 °C

6.1: thionyl chloride / 1 h / 65 °C

7.1: tetrahydrofuran / 1 h / 0 - 20 °C

With sodium periodate; thionyl chloride; dichlorobis(tri-O-tolylphosphine)palladium; water; sodium hydride; sodium cyanoborohydride; potassium carbonate; acetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; mineral oil; 4.1: Suzuki coupling;
DOI:10.1021/jm300011d

Reference yield:

: 1131219-59-4
methyl 4-(1-oxo-2-(2-(pyrrolidin-1-yl)ethyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)benzoate

: 1131224-10-6
N-methoxy-N-methyl-4-[1-oxo-2-(2-pyrrolidin-1-ylethyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: water; sodium hydroxide / ethanol / 3 h / 20 °C

2: thionyl chloride / 1 h / 65 °C

3: tetrahydrofuran / 1 h / 0 - 20 °C

With thionyl chloride; water; sodium hydroxide; In tetrahydrofuran; ethanol;
DOI:10.1021/jm300011d

Reference yield:

: 1131222-89-3
4-(1-oxo-2-(2-(pyrrolidin-1-yl)ethyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)benzoic acid

: 1131224-10-6
N-methoxy-N-methyl-4-[1-oxo-2-(2-pyrrolidin-1-ylethyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 1 h / 65 °C

2: tetrahydrofuran / 1 h / 0 - 20 °C

With thionyl chloride; In tetrahydrofuran;
DOI:10.1021/jm300011d