N,O-Dimethylhydroxylamine hydrochloride

Base Information

• Chemical Name: N,O-Dimethylhydroxylamine hydrochloride
• CAS No.: 6638-79-5
• Molecular Formula: C2H7NO^.HCl
• Molecular Weight: 97.5446
• Hs Code.: 29280090
• Mol file: 6638-79-5.mol

Synonyms:Methanamine,N-methoxy-, hydrochloride (9CI);Methoxymethylamine hydrochloride;N-Methoxy-N-methylamine hydrochloride;N-Methoxymethylamine hydrochloride;N-Methyl-N-methoxyamine hydrochloride;O,N-Dimethylhydroxylamine hydrochloride;O-Methyl hydroxy(methyl)amine hydrochloride;N,O-Dimethylhydroxylamine hcl;

Chemical Property of N,O-Dimethylhydroxylamine hydrochloride

Chemical Property:

• Appearance/Colour: white to off-white crystals or crystalline powder
• Vapor Pressure: 1710mmHg at 25°C
• Melting Point: 112-115 °C
• Boiling Point: 2.9 °C at 760 mmHg
• PSA: 21.26000
• Density: 1 g/cm3
• LogP: 0.96010
• Storage Temp.: Store at RT.
• Sensitive.: Hygroscopic
• Solubility.: DMSO, Methanol
• Water Solubility.: SOLUBLE
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 97.0294416
• Heavy Atom Count: 5
• Complexity: 10

Purity/Quality:

99% ^*data from raw suppliers

N,O-Dimethylhydroxylamine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/38-36/37/38
• Safety Statements: 26-36-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[NH2+]OC.[Cl-]
• Uses: N,O-Dimethylhydroxylamine hydrochloride is used for preparation of an inhibitor of the NLS-derived BC peptides. N,O-Dimethylhydroxylamine hydrochloride is used as a reagent in the preparation of 2-acyloxazoles from 2-oxazolemagnesium chloride and N-methoxy-N-methyl-3-oxo-butyramide from diketene. It is also used in amide coupling reactions to form Weinreb amides, which are useful in the Weinreb ketone synthesis. In addition, it is used in the preparation of an inhibitor of the NLS-derived BC peptides. Reagent for the preparation of Weinreb amides recently used in the synthesis of 2-acyloxazoles from 2-oxazolemagnesium chloride.

Technology Process of N,O-Dimethylhydroxylamine hydrochloride

There total 10 articles about N,O-Dimethylhydroxylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

→ N,O-dimethylhydroxylamine*hydrochloride (6638-79-5)

Guidance literature:

Reference yield: 46.0%

N-methoxy-N-methylbenzenesulfonamide → N,O-dimethylhydroxylamine*hydrochloride (6638-79-5)

Guidance literature:

N-methoxy-N-methylbenzenesulfonamide; With iodine; magnesium; In methanol; for 0.5h; Sonication;

With hydrogenchloride; In water; pH=1;

DOI:10.1002/ejoc.201800526

Reference yield:

N,0-dimethylhydroxylamine (1117-97-1) → N,O-dimethylhydroxylamine*hydrochloride (6638-79-5)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

4-amino-2-ethylsulfanylpyrimidine-5-carboxylic acid metoxymethylamide

1-bromo-4,5-difluoro-2-methoxybenzene

trimethylaluminum

N,0-dimethylhydroxylamine

Downstream raw materials:

N-methoxy-N-methyl-3-oxobutanamide

2-methyl-N-methoxy-N-methylbenzamide

N,N'-dimethoxy-N,N'-dimethyl urea

N-methoxy-N-methyltrifluoroacetamide

Refernces

• 1、 -. "One-pot method for preparing O-alkyl hydroxylamine hydrochloride and N,O-dialkyl hydroxylamine hydrochloride". Paragraph 0032-0033. . Retrieved 2020/10/20.
• 2、 -. "HIV INTEGRASE INHIBITORS". . . Retrieved 2015/09/22.