(R)-2-{2-[((R)-4-tert-Butoxycarbonylamino-4-methoxycarbonyl-butyryl)-methyl-amino]-acetylamino}-succinic acid 4-benzyl ester 1-methyl ester

Base Information

Chemical Name:(R)-2-{2-[((R)-4-tert-Butoxycarbonylamino-4-methoxycarbonyl-butyryl)-methyl-amino]-acetylamino}-succinic acid 4-benzyl ester 1-methyl ester
CAS No.:182748-75-0
Molecular Formula:C₂₆H₃₇N₃O₁₀
Molecular Weight:551.594
Hs Code.:

Synonyms:(R)-2-{2-[((R)-4-tert-Butoxycarbonylamino-4-methoxycarbonyl-butyryl)-methyl-amino]-acetylamino}-succinic acid 4-benzyl ester 1-methyl ester

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Chemical Property of (R)-2-{2-[((R)-4-tert-Butoxycarbonylamino-4-methoxycarbonyl-butyryl)-methyl-amino]-acetylamino}-succinic acid 4-benzyl ester 1-methyl ester

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Technology Process of (R)-2-{2-[((R)-4-tert-Butoxycarbonylamino-4-methoxycarbonyl-butyryl)-methyl-amino]-acetylamino}-succinic acid 4-benzyl ester 1-methyl ester

There total 8 articles about (R)-2-{2-[((R)-4-tert-Butoxycarbonylamino-4-methoxycarbonyl-butyryl)-methyl-amino]-acetylamino}-succinic acid 4-benzyl ester 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 165451-30-9
H-D-Asp(OBn)-OMe

: 196938-91-7
(N-tert-butoxycarbonyl)-[α-methyl (2R)-glutamyl]-γ-sarcosine

: 182748-75-0
(R)-2-{2-[((R)-4-tert-Butoxycarbonylamino-4-methoxycarbonyl-butyryl)-methyl-amino]-acetylamino}-succinic acid 4-benzyl ester 1-methyl ester

Guidance literature:: With activating agent;
DOI:10.1016/0040-4039(96)01515-8

Reference yield:

: 35793-73-8
N-(tert-butyloxycarbonyl)-γ-benzyl-D-glutamic acid

: 182748-75-0
(R)-2-{2-[((R)-4-tert-Butoxycarbonylamino-4-methoxycarbonyl-butyryl)-methyl-amino]-acetylamino}-succinic acid 4-benzyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / diethyl ether / 0.5 h / 0 °C

2: 100 percent / H₂ / 10percent Pd/C / ethanol / 3 h / Ambient temperature

3: 4-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

4: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 0.75 h / Ambient temperature

5: 98 percent / H₂ / 10percent Pd/C / ethanol / 3 h / Ambient temperature

6: N-methylmorpholine / tetrahydrofuran; dimethylformamide / 0.83 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 55227-00-4
α-Methyl (2R)-N-(tert-butoxycarbonyl)glutamate ester

: 182748-75-0
(R)-2-{2-[((R)-4-tert-Butoxycarbonylamino-4-methoxycarbonyl-butyryl)-methyl-amino]-acetylamino}-succinic acid 4-benzyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

2: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 0.75 h / Ambient temperature

3: 98 percent / H₂ / 10percent Pd/C / ethanol / 3 h / Ambient temperature

4: N-methylmorpholine / tetrahydrofuran; dimethylformamide / 0.83 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;