(1S,5R)-3-(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}propyl)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane

Base Information

Chemical Name:(1S,5R)-3-(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}propyl)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane
CAS No.:917917-17-0
Molecular Formula:C₂₁H₃₁F₄NOSi
Molecular Weight:417.562
Hs Code.:

Synonyms:(1S,5R)-3-(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}propyl)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane

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Chemical Property of (1S,5R)-3-(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}propyl)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane

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Technology Process of (1S,5R)-3-(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}propyl)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane

There total 4 articles about (1S,5R)-3-(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}propyl)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 863679-54-3
(1S,5R)-1-[2-fluoro-4-(trifluoromethyl)pheny|]-3-azabicyclo-[3.1.0]hexane

: 89031-84-5
3-(tert-butyldimethylsilyloxy)propyl bromide

: 917917-17-0
(1S,5R)-3-(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}propyl)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane

Guidance literature:: With triethylamine; sodium iodide; In tetrahydrofuran; at 20 ℃; for 20h;

Reference yield:

: 69409-98-9
2-fluoro-4-(trifluoromethyl)aniline

: 917917-17-0
(1S,5R)-3-(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}propyl)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane

Guidance literature:: Multi-step reaction with 5 steps

1.1: tert.-butylnitrite; copper dichloride / acetonitrile / 1 h / 0 - 20 °C

2.1: sodium hydride / dimethyl sulfoxide / 0.5 h

3.1: borane-THF / tetrahydrofuran / 24 h / 0 - 65 °C

3.2: 20 °C

4.1: (R)-10-camphorsulfonic acid / acetonitrile / 1.08 h / 20 °C / Heating / reflux

4.2: 20 °C

5.1: triethylamine; sodium iodide / tetrahydrofuran / 20 h / 20 °C

With tert.-butylnitrite; borane-THF; (R)-10-camphorsulfonic acid; sodium hydride; triethylamine; sodium iodide; copper dichloride; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile;

Reference yield:

: (1R,5S/1S,5R)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane

: 917917-17-0
(1S,5R)-3-(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}propyl)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane

Guidance literature:: Multi-step reaction with 2 steps

1.1: (R)-10-camphorsulfonic acid / acetonitrile / 1.08 h / 20 °C / Heating / reflux

1.2: 20 °C

2.1: triethylamine; sodium iodide / tetrahydrofuran / 20 h / 20 °C

With (R)-10-camphorsulfonic acid; triethylamine; sodium iodide; In tetrahydrofuran; acetonitrile;