2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidine-4-yl]phenyl}ethanol

Base Information

Chemical Name:2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidine-4-yl]phenyl}ethanol
CAS No.:912346-57-7
Molecular Formula:C₄₂H₆₂N₂O₇SSi
Molecular Weight:767.115
Hs Code.:

2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidine-4-yl]phenyl}ethanol

Synonyms:2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidine-4-yl]phenyl}ethanol

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Chemical Property of 2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidine-4-yl]phenyl}ethanol

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Technology Process of 2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidine-4-yl]phenyl}ethanol

There total 6 articles about 2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidine-4-yl]phenyl}ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₂H₆₃N₃O₆SSi

: 912346-57-7
2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidine-4-yl]phenyl}ethanol

Guidance literature:: C₄₂H₆₃N₃O₆SSi; With borane-THF; In tetrahydrofuran; for 2h;

With methanol; In trifluoroacetic acid;

Reference yield:

: 912346-58-8
{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-4-yl]phenyl}acetonitrile

: 912346-57-7
2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidine-4-yl]phenyl}ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / dichloromethane / 2.5 h / -78 - 20 °C

2: borane-THF / tetrahydrofuran / 2 h

With borane-THF; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane;

Reference yield:

: 911855-73-7
(4-{(3R,4R,5S)-3-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-triisopropylsilanyloxy-piperidin-4-yl}-phenyl)-methanol

: 912346-57-7
2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidine-4-yl]phenyl}ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / water; ethyl acetate / 14 h / 20 °C

2: methanesulfonyl chloride; tetrabutyl-ammonium chloride; triethylamine / dichloromethane / 6 h / 20 °C

3: 18-crown-6 ether / tetrahydrofuran; acetonitrile / 2 h / 50 °C

4: diisobutylaluminium hydride / dichloromethane / 2.5 h / -78 - 20 °C

5: borane-THF / tetrahydrofuran / 2 h

With borane-THF; 18-crown-6 ether; tetrabutyl-ammonium chloride; diisobutylaluminium hydride; sodium carbonate; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetonitrile;