6-[(3R,4R,5S)-4-[4-(2-methoxyethyl)phenyl]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine

Base Information

Chemical Name:6-[(3R,4R,5S)-4-[4-(2-methoxyethyl)phenyl]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine
CAS No.:912346-56-6
Molecular Formula:C₄₃H₆₄N₂O₇SSi
Molecular Weight:781.142
Hs Code.:

6-[(3R,4R,5S)-4-[4-(2-methoxyethyl)phenyl]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine

Synonyms:6-[(3R,4R,5S)-4-[4-(2-methoxyethyl)phenyl]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine

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Chemical Property of 6-[(3R,4R,5S)-4-[4-(2-methoxyethyl)phenyl]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine

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Technology Process of 6-[(3R,4R,5S)-4-[4-(2-methoxyethyl)phenyl]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine

There total 7 articles about 6-[(3R,4R,5S)-4-[4-(2-methoxyethyl)phenyl]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 912346-57-7
2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidine-4-yl]phenyl}ethanol

: 74-88-4
methyl iodide

: 912346-56-6
6-[(3R,4R,5S)-4-[4-(2-methoxyethyl)phenyl]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 6h;

Reference yield:

: 911855-73-7
(4-{(3R,4R,5S)-3-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-triisopropylsilanyloxy-piperidin-4-yl}-phenyl)-methanol

: 912346-56-6
6-[(3R,4R,5S)-4-[4-(2-methoxyethyl)phenyl]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate / water; ethyl acetate / 14 h / 20 °C

2: methanesulfonyl chloride; tetrabutyl-ammonium chloride; triethylamine / dichloromethane / 6 h / 20 °C

3: 18-crown-6 ether / tetrahydrofuran; acetonitrile / 2 h / 50 °C

4: diisobutylaluminium hydride / dichloromethane / 2.5 h / -78 - 20 °C

5: borane-THF / tetrahydrofuran / 2 h

6: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 6 h / 20 °C

With borane-THF; 18-crown-6 ether; tetrabutyl-ammonium chloride; sodium hydride; diisobutylaluminium hydride; sodium carbonate; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: C₄₂H₆₃N₃O₆SSi

: 912346-56-6
6-[(3R,4R,5S)-4-[4-(2-methoxyethyl)phenyl]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine

Guidance literature:: Multi-step reaction with 2 steps

1: borane-THF / tetrahydrofuran / 2 h

2: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 6 h / 20 °C

With borane-THF; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;