4'-[4-(2-hydroxy-1-tetrahydropyran-2-yloxyprop-2-yl)thien-2-ylthio]acetophenone ethylene acetal

Base Information

Chemical Name:4'-[4-(2-hydroxy-1-tetrahydropyran-2-yloxyprop-2-yl)thien-2-ylthio]acetophenone ethylene acetal
CAS No.:161386-57-8
Molecular Formula:C₂₂H₂₈O₅S₂
Molecular Weight:436.593
Hs Code.:

Synonyms:4'-[4-(2-hydroxy-1-tetrahydropyran-2-yloxyprop-2-yl)thien-2-ylthio]acetophenone ethylene acetal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4'-[4-(2-hydroxy-1-tetrahydropyran-2-yloxyprop-2-yl)thien-2-ylthio]acetophenone ethylene acetal

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Technology Process of 4'-[4-(2-hydroxy-1-tetrahydropyran-2-yloxyprop-2-yl)thien-2-ylthio]acetophenone ethylene acetal

There total 7 articles about 4'-[4-(2-hydroxy-1-tetrahydropyran-2-yloxyprop-2-yl)thien-2-ylthio]acetophenone ethylene acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 161386-57-8
4'-[4-(2-hydroxy-1-tetrahydropyran-2-yloxyprop-2-yl)thien-2-ylthio]acetophenone ethylene acetal

Guidance literature:

Reference yield:

: 3814-20-8
4-mercaptoacetophenone

: 161386-57-8
4'-[4-(2-hydroxy-1-tetrahydropyran-2-yloxyprop-2-yl)thien-2-ylthio]acetophenone ethylene acetal

Guidance literature:: Multi-step reaction with 4 steps

1: DFMSO / 18 h / Ambient temperature

2: 76 percent / triethyl orthoformate, PTSA / toluene / 3 h / 60 °C

3: 1.) BuLi

4: 1.) n-BuLi / 1.) hexanes, ether, -70 deg C, 1 h, 2.) hexanes, ether, -70 deg C, 1 h

With n-butyllithium; toluene-4-sulfonic acid; orthoformic acid triethyl ester; In toluene;
DOI:10.1021/jm00020a008

Reference yield:

: 1778-09-2
4-(Methylthio)acetophenone

: 161386-57-8
4'-[4-(2-hydroxy-1-tetrahydropyran-2-yloxyprop-2-yl)thien-2-ylthio]acetophenone ethylene acetal

Guidance literature:: Multi-step reaction with 5 steps

1: NaSMe / dimethylformamide / 1.5 h / 150 °C

2: DFMSO / 18 h / Ambient temperature

3: 76 percent / triethyl orthoformate, PTSA / toluene / 3 h / 60 °C

4: 1.) BuLi

5: 1.) n-BuLi / 1.) hexanes, ether, -70 deg C, 1 h, 2.) hexanes, ether, -70 deg C, 1 h

With n-butyllithium; toluene-4-sulfonic acid; orthoformic acid triethyl ester; sodium thiomethoxide; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00020a008