2-(3-cyano-4-furan-2-yl-6-thiophen-2-yl-pyridin-2-yloxy)-2-phenyl-N-(2H-tetrazol-5-yl)-acetamide

Base Information

Chemical Name:2-(3-cyano-4-furan-2-yl-6-thiophen-2-yl-pyridin-2-yloxy)-2-phenyl-N-(2H-tetrazol-5-yl)-acetamide
CAS No.:956130-96-4
Molecular Formula:C₂₃H₁₅N₇O₃S
Molecular Weight:469.483
Hs Code.:

Synonyms:2-(3-cyano-4-furan-2-yl-6-thiophen-2-yl-pyridin-2-yloxy)-2-phenyl-N-(2H-tetrazol-5-yl)-acetamide

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Chemical Property of 2-(3-cyano-4-furan-2-yl-6-thiophen-2-yl-pyridin-2-yloxy)-2-phenyl-N-(2H-tetrazol-5-yl)-acetamide

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Technology Process of 2-(3-cyano-4-furan-2-yl-6-thiophen-2-yl-pyridin-2-yloxy)-2-phenyl-N-(2H-tetrazol-5-yl)-acetamide

There total 4 articles about 2-(3-cyano-4-furan-2-yl-6-thiophen-2-yl-pyridin-2-yloxy)-2-phenyl-N-(2H-tetrazol-5-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 4418-61-5
5-aminotetrazole

: 2-[3-cyano-4-(2-furyl)-6-(2-thienyl)-2-pyridinyl]oxy-2-phenylacetic acid

: 956130-96-4
2-(3-cyano-4-furan-2-yl-6-thiophen-2-yl-pyridin-2-yloxy)-2-phenyl-N-(2H-tetrazol-5-yl)-acetamide

Guidance literature:: 2-[3-cyano-4-(2-furyl)-6-(2-thienyl)-2-pyridinyl]oxy-2-phenylacetic acid; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at -5 - 20 ℃; for 0.5h;

5-aminotetrazole; With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 18.0333h;

Reference yield:

: (3-cyano-4-furan-2-yl-6-thiophen-2-yl-pyridin-2-yloxy)-phenyl-acetic acid allyl ester

: 956130-96-4
2-(3-cyano-4-furan-2-yl-6-thiophen-2-yl-pyridin-2-yloxy)-2-phenyl-N-(2H-tetrazol-5-yl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1.08 h / 20 °C

2.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.5 h / -5 - 20 °C

2.2: 18.03 h / 20 °C

With sodium tetrahydroborate; triethylamine; isobutyl chloroformate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran;

Reference yield:

: 81682-91-9
LDN-0100863

: 956130-96-4
2-(3-cyano-4-furan-2-yl-6-thiophen-2-yl-pyridin-2-yloxy)-2-phenyl-N-(2H-tetrazol-5-yl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; sodium iodide / acetone / 4 h / Heating / reflux

2.1: sodium tetrahydroborate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1.08 h / 20 °C

3.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.5 h / -5 - 20 °C

3.2: 18.03 h / 20 °C

With sodium tetrahydroborate; potassium carbonate; triethylamine; sodium iodide; isobutyl chloroformate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; acetone;