1-([1,1’-biphenyl]-4-yl)-N-benzyl-N-methylmethanamine

Base Information

• Chemical Name: 1-([1,1’-biphenyl]-4-yl)-N-benzyl-N-methylmethanamine
• CAS No.: 262371-18-6
• Molecular Formula: C₂₁H₂₁N
• Molecular Weight: 287.404
• Mol file: 262371-18-6.mol

Synonyms:1-([1,1’-biphenyl]-4-yl)-N-benzyl-N-methylmethanamine

Chemical Property of 1-([1,1’-biphenyl]-4-yl)-N-benzyl-N-methylmethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-([1,1’-biphenyl]-4-yl)-N-benzyl-N-methylmethanamine

There total 6 articles about 1-([1,1’-biphenyl]-4-yl)-N-benzyl-N-methylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-(fluoromethyl)-1,1’-biphenyl + benzyl-methyl-amine (103-67-3) → 1-([1,1’-biphenyl]-4-yl)-N-benzyl-N-methylmethanamine (262371-18-6)

Guidance literature:

With 1,1,1-tri(hydroxymethyl)propane; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.3762/bjoc.9.283

Reference yield:

biphenyl-4-yl methanol (3597-91-9) → 1-([1,1’-biphenyl]-4-yl)-N-benzyl-N-methylmethanamine (262371-18-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrochloric acid / 100 °C / im Rohr

With hydrogenchloride;

DOI:10.1016/S0940-9602(02)80062-0

Reference yield:

p-phenylbenzyl bromide (2567-29-5) → 1-([1,1’-biphenyl]-4-yl)-N-benzyl-N-methylmethanamine (262371-18-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / acetonitrile / 18 h / 25 °C

2: water / isopropyl alcohol / 18 h / 70 °C

With tetrabutyl ammonium fluoride; water; In isopropyl alcohol; acetonitrile;

DOI:10.1021/ol400765a

upstream raw materials:

ortho-methylbenzylamine

biphenyl-4-methylchloride

p-phenylbenzyl bromide

benzyl-methyl-amine

Downstream raw materials:

N-benzyl-N-methyl cyanamide

p-phenylbenzyl bromide