(2R,4S,5S,6S)-1-(1,3-dithian-2-yl)-5-hydroxy-2,4-dimethyl-6-tosyloxyheptane

Base Information

Chemical Name:(2R,4S,5S,6S)-1-(1,3-dithian-2-yl)-5-hydroxy-2,4-dimethyl-6-tosyloxyheptane
CAS No.:610302-63-1
Molecular Formula:C₁₉H₃₀O₄S₃
Molecular Weight:418.643
Hs Code.:

Synonyms:(2R,4S,5S,6S)-1-(1,3-dithian-2-yl)-5-hydroxy-2,4-dimethyl-6-tosyloxyheptane

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Chemical Property of (2R,4S,5S,6S)-1-(1,3-dithian-2-yl)-5-hydroxy-2,4-dimethyl-6-tosyloxyheptane

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Technology Process of (2R,4S,5S,6S)-1-(1,3-dithian-2-yl)-5-hydroxy-2,4-dimethyl-6-tosyloxyheptane

There total 9 articles about (2R,4S,5S,6S)-1-(1,3-dithian-2-yl)-5-hydroxy-2,4-dimethyl-6-tosyloxyheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 109-80-8
1.3-propanedithiol

: 610302-61-9
[2S,3R,5S,6S,6(1S)]-2-methoxy-3,5-dimethyl-6-(1-tosyloxyethyl)tetrahydropyran

: 610302-63-1
(2R,4S,5S,6S)-1-(1,3-dithian-2-yl)-5-hydroxy-2,4-dimethyl-6-tosyloxyheptane

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃; for 24h;

Reference yield:

: 85593-49-3
1,6-anhydro-2,3,4-trideoxy-2,4-di-C-methyl-β-D-ribo-hexopyranoside

: 610302-63-1
(2R,4S,5S,6S)-1-(1,3-dithian-2-yl)-5-hydroxy-2,4-dimethyl-6-tosyloxyheptane

Guidance literature:: Multi-step reaction with 5 steps

1: 45 percent / Dowex 50W (H(+)) / 7.5 h / 20 °C

2: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 0 °C

3: 301.6 mg / tetrahydrofuran / 17 h / 0 °C

4: 96 percent / DMAP / pyridine / 24 h / 20 °C

5: 100 percent / BF₃*OEt₂ / CH₂Cl₂ / 24 h / 0 °C

With dmap; oxalyl dichloride; Dowex 50W (H(+)); boron trifluoride diethyl etherate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; pyridine; dichloromethane;

Reference yield:

: 128790-96-5
Methanesulfonic acid (1S,2R,3S,4R,5R)-2-methyl-4-phenylsulfanylmethyl-6,8-dioxa-bicyclo[3.2.1]oct-3-yl ester

: 610302-63-1
(2R,4S,5S,6S)-1-(1,3-dithian-2-yl)-5-hydroxy-2,4-dimethyl-6-tosyloxyheptane

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / Na; liq. NH₃ / tetrahydrofuran / 1 h / -78 °C

2: 45 percent / Dowex 50W (H(+)) / 7.5 h / 20 °C

3: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 0 °C

4: 301.6 mg / tetrahydrofuran / 17 h / 0 °C

5: 96 percent / DMAP / pyridine / 24 h / 20 °C

6: 100 percent / BF₃*OEt₂ / CH₂Cl₂ / 24 h / 0 °C

With dmap; oxalyl dichloride; Dowex 50W (H(+)); boron trifluoride diethyl etherate; ammonia; sodium; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; pyridine; dichloromethane;