benzyl (4S)-4-(tert-butoxycarbonyl)amino-5-[(2-methoxyethoxy)methoxy]pentanoate

Base Information

• Chemical Name: benzyl (4S)-4-(tert-butoxycarbonyl)amino-5-[(2-methoxyethoxy)methoxy]pentanoate
• CAS No.: 299432-52-3
• Molecular Formula: C₂₁H₃₃NO₇
• Molecular Weight: 411.496
• Mol file: 299432-52-3.mol

Synonyms:benzyl (4S)-4-(tert-butoxycarbonyl)amino-5-[(2-methoxyethoxy)methoxy]pentanoate

Chemical Property of benzyl (4S)-4-(tert-butoxycarbonyl)amino-5-[(2-methoxyethoxy)methoxy]pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (4S)-4-(tert-butoxycarbonyl)amino-5-[(2-methoxyethoxy)methoxy]pentanoate

There total 1 articles about benzyl (4S)-4-(tert-butoxycarbonyl)amino-5-[(2-methoxyethoxy)methoxy]pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Methoxyethoxymethyl chloride (3970-21-6) + benzyl (S)-4-(t-butyloxycarbonylamino)-5-hydroxypentanoate (79069-62-8) → benzyl (4S)-4-(tert-butoxycarbonyl)amino-5-[(2-methoxyethoxy)methoxy]pentanoate (299432-52-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2006.05.040

Reference yield: 100.0%

benzyl (4S)-4-(tert-butoxycarbonyl)amino-5-[(2-methoxyethoxy)methoxy]pentanoate (299432-52-3) + 4-Phenoxybenzoic acid (2215-77-2) → benzyl (4S)-5-(2-methoxyethoxy)methoxy-4-[(4-phenoxybenzoyl)amino]pentanoate (911050-53-8)

Guidance literature:

benzyl (4S)-4-(tert-butoxycarbonyl)amino-5-[(2-methoxyethoxy)methoxy]pentanoate; With trifluoroacetic acid; In dichloromethane; water; at 0 ℃; for 0.5h;

4-Phenoxybenzoic acid; With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1016/j.bmc.2006.05.040

Reference yield:

benzyl (4S)-4-(tert-butoxycarbonyl)amino-5-[(2-methoxyethoxy)methoxy]pentanoate (299432-52-3) + methyl iodide (74-88-4) → benzyl (2S,4S)-4-(tert-butoxycarbonyl)amino-5-(2-methoxyethoxy)methoxy-2-methylpentanoate (911050-95-8)

Guidance literature:

benzyl (4S)-4-(tert-butoxycarbonyl)amino-5-[(2-methoxyethoxy)methoxy]pentanoate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at -78 ℃; for 3h;

DOI:10.1016/j.bmc.2006.05.040

upstream raw materials:

2-Methoxyethoxymethyl chloride

benzyl (S)-4-(t-butyloxycarbonylamino)-5-hydroxypentanoate

Downstream raw materials:

benzyl (4S)-5-(2-methoxyethoxy)methoxy-4-[(4-phenoxybenzoyl)amino]pentanoate

benzyl (2S,4S)-4-(tert-butoxycarbonyl)amino-5-(2-methoxyethoxy)methoxy-2-methylpentanoate

benzyl (2S,4S)-5-(2-methoxyethoxy)methoxy-2-methyl-4-[(4-phenoxybenzoyl)amino]pentanoate

benzyl (2S,4S)-2-ethyl-5-(2-methoxyethoxy)methoxy-4-[(4-phenoxybenzoyl)amino]pentanoate