(+)-(2R)-2-[(R)-hydroxy(phenyl)methyl]-4-[(S)-1-phenylethyl]morpholin-3-one

Base Information

Chemical Name:(+)-(2R)-2-[(R)-hydroxy(phenyl)methyl]-4-[(S)-1-phenylethyl]morpholin-3-one
CAS No.:1340544-14-0
Molecular Formula:C₁₉H₂₁NO₃
Molecular Weight:311.381
Hs Code.:

Synonyms:(+)-(2R)-2-[(R)-hydroxy(phenyl)methyl]-4-[(S)-1-phenylethyl]morpholin-3-one

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Chemical Property of (+)-(2R)-2-[(R)-hydroxy(phenyl)methyl]-4-[(S)-1-phenylethyl]morpholin-3-one

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Technology Process of (+)-(2R)-2-[(R)-hydroxy(phenyl)methyl]-4-[(S)-1-phenylethyl]morpholin-3-one

There total 4 articles about (+)-(2R)-2-[(R)-hydroxy(phenyl)methyl]-4-[(S)-1-phenylethyl]morpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: C₁₉H₂₁NO₃

: 1340544-14-0
(+)-(2R)-2-[(R)-hydroxy(phenyl)methyl]-4-[(S)-1-phenylethyl]morpholin-3-one

: 1340543-93-2
(-)-(2S)-2-[(S)-hydroxy(phenyl)methyl]-4-[(S)-1-phenylethyl]morpholin-3-one

Guidance literature:: With sodium; In tetrahydrofuran; at 20 ℃; for 0.333333h; regiospecific reaction;
DOI:10.1055/s-0030-1260064

Reference yield:

: C₁₂H₁₆BrNO₂

: 1340544-14-0
(+)-(2R)-2-[(R)-hydroxy(phenyl)methyl]-4-[(S)-1-phenylethyl]morpholin-3-one

: 1340543-93-2
(-)-(2S)-2-[(S)-hydroxy(phenyl)methyl]-4-[(S)-1-phenylethyl]morpholin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 12 h / 0 - 20 °C

3: sodium / tetrahydrofuran / 0.33 h / 20 °C

With sodium; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-0030-1260064

Reference yield:

: 2627-86-3
(S)-1-phenyl-ethylamine

: 1340544-14-0
(+)-(2R)-2-[(R)-hydroxy(phenyl)methyl]-4-[(S)-1-phenylethyl]morpholin-3-one

: 1340543-93-2
(-)-(2S)-2-[(S)-hydroxy(phenyl)methyl]-4-[(S)-1-phenylethyl]morpholin-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: water / 0.33 h / Sonication

2: triethylamine / dichloromethane / -10 °C

3: dichloromethane / 20 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 12 h / 0 - 20 °C

5: sodium / tetrahydrofuran / 0.33 h / 20 °C

With sodium; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1055/s-0030-1260064