2-(1-Phenyl-ethylamino)-ethanol

Base Information

• Chemical Name: 2-(1-Phenyl-ethylamino)-ethanol
• CAS No.: 6623-43-4
• Molecular Formula: C10H15 N O
• Molecular Weight: 165.235
• Hs Code.: 2922199090
• NSC Number: 54968,35362
• DSSTox Substance ID: DTXSID60927941
• Nikkaji Number: J78.162B
• Mol file: 6623-43-4.mol

Synonyms:6623-43-4;2-(1-Phenyl-ethylamino)-ethanol;2-(1-phenylethylamino)ethanol;2-((1-Phenylethyl)amino)ethanol;2-[(1-phenylethyl)amino]ethanol;1331-41-5;2-[(1-Phenylethyl)Amino]Ethan-1-Ol;((alpha-Methylbenzyl)amino)ethanol;N-Hydroxyethyl-alpha-methylbenzylamine;ETHANOL, ((alpha-METHYLBENZYL)AMINO)-;2-(.alpha.-Methybenzylamino)ethanol;2-[[(1R)-1-phenylethyl]amino]ethanol;(S)-(-)-N-(2-Hydroxyethyl)-alpha-phenylethylamine;NSC54968;2-(1-Phenylethyl)aminoethanol;SCHEMBL3158749;NIOSH/KM1820000;DTXSID60927941;Ethanol, [(1-phenylethyl)amino]-;Ethanol, 2-(1-phenylethyl)amino-;NSC35362;NSC-35362;NSC-54968;AKOS000253082;SB46776;SB76328;SB84035;alpha-Methylbenzylamine, N-hydroxyethyl-;AS-60742;Ethanol, [(.alpha.-methylbenzyl)amino]-;LS-66879;LS-67015;N-(2-hydroxyethyl)-alpha-methylbenzylamine;FT-0691517;KM18200000;2-[(1-Phenylethyl)amino]ethanol, AldrichCPR;EN300-162809;A924117;Z137803364

Chemical Property of 2-(1-Phenyl-ethylamino)-ethanol

Chemical Property:

• Vapor Pressure: 0.00129mmHg at 25°C
• Boiling Point: 285.7°C at 760 mmHg
• PKA: 14.74±0.10(Predicted)
• Flash Point: 114.4°C
• PSA: 32.26000
• Density: 1.017g/cm³
• LogP: 1.72040
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 165.115364102
• Heavy Atom Count: 12
• Complexity: 110

Purity/Quality:

97% ^*data from raw suppliers

2-(1-Phenyl-ethylamino)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=CC=C1)NCCO

Technology Process of 2-(1-Phenyl-ethylamino)-ethanol

There total 14 articles about 2-(1-Phenyl-ethylamino)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

ethanolamine (141-43-5) + acetophenone (98-86-2) → 2-(1-phenyl-ethylamino)-ethanol (6623-43-4)

Guidance literature:

ethanolamine; acetophenone; With titanium(IV) isopropylate; In methanol; at 20 ℃; for 48h; Inert atmosphere;

With sodium tetrahydroborate; In methanol; at 0 ℃; for 2h;

Reference yield: 91.0%

oxirane (75-21-8,99932-75-9) + (S)-1-phenyl-ethylamine (2627-86-3) → (S)-(-)-N-(2-hydroxyethyl)-α-methylbenzylamine (6623-43-4,80548-31-8,66849-29-4)

Guidance literature:

In water; for 0.333333h; Sonication;

DOI:10.1055/s-0030-1260064

Reference yield: 87.0%

(-)-α-methylbenzylamine (2627-86-3) + 2-chloro-ethanol (107-07-3) → (-)-(2-hydroxyethyl)(1-phenylethyl)amine (6623-43-4,66849-29-4,80548-31-8)

Guidance literature:

In water; for 5h; Heating;

upstream raw materials:

ethanolamine

acetophenone

(2-hydroxyethyl)-formamide

ethanol

Downstream raw materials:

N-(2-hydroxy-ethyl)-N-(1-phenyl-ethyl)-β-alanine nitrile

(1-phenyl-ethyl)-(2-vinyloxy-ethyl)-carbamic acid methyl ester

7-bromo-2-(1-phenylethyl)-3,4-dihydro-1H-pyrido[1,2-a]pyrazine-1,6(2H)-dione

2-(1-phenylethyl)-3,4-dihydro-1H-pyrido[1,2-a]pyrazine-1,6(2H)-dione