(S)-3-amino-1,4,4-trimethylpyrrolidin-2-one O,O-di-p-toluoyl-(2R,3R)-tartrate

Base Information

Chemical Name:(S)-3-amino-1,4,4-trimethylpyrrolidin-2-one O,O-di-p-toluoyl-(2R,3R)-tartrate
CAS No.:1316216-26-8
Molecular Formula:C₇H₁₄N₂O*C₂₀H₁₈O₈
Molecular Weight:528.559
Hs Code.:

Synonyms:(S)-3-amino-1,4,4-trimethylpyrrolidin-2-one O,O-di-p-toluoyl-(2R,3R)-tartrate

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Chemical Property of (S)-3-amino-1,4,4-trimethylpyrrolidin-2-one O,O-di-p-toluoyl-(2R,3R)-tartrate

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Technology Process of (S)-3-amino-1,4,4-trimethylpyrrolidin-2-one O,O-di-p-toluoyl-(2R,3R)-tartrate

There total 8 articles about (S)-3-amino-1,4,4-trimethylpyrrolidin-2-one O,O-di-p-toluoyl-(2R,3R)-tartrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 32634-66-5
Di-p-toluoyl-L-tartaric acid

: 1316216-24-6
(S)-3-amino-1,4,4-trimethylpyrrolidin-2-one

: 1316216-26-8
(S)-3-amino-1,4,4-trimethylpyrrolidin-2-one O,O-di-p-toluoyl-(2R,3R)-tartrate

Guidance literature:: In methanol;
DOI:10.1016/j.tetasy.2011.04.002

Reference yield:

: 1316216-37-1
(3S,1'R)-1,4,4-trimethyl-3-[(1-phenylethyl)amino]pyrrolidin-2-one (S)-mandelate

: 1316216-26-8
(S)-3-amino-1,4,4-trimethylpyrrolidin-2-one O,O-di-p-toluoyl-(2R,3R)-tartrate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / dichloromethane; water

2: hydrogenchloride; 5% Pd(II)/C(eggshell); hydrogen / methanol / 24 h / 20 °C / 760.05 Torr

3: methanol

With hydrogenchloride; 5% Pd(II)/C(eggshell); hydrogen; sodium hydroxide; In methanol; dichloromethane; water;
DOI:10.1016/j.tetasy.2011.04.002

Reference yield:

: 1316216-32-6
(R)-1,4,4-trimethyl-3-[(1-phenylethyl)imino]pyrrolidin-2-one

: 1316216-26-8
(S)-3-amino-1,4,4-trimethylpyrrolidin-2-one O,O-di-p-toluoyl-(2R,3R)-tartrate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium cyanoborohydride; acetic acid / methanol / 4.75 h / -78 °C

1.2: 20 °C / pH 12 - 13

2.1: hydrogenchloride; 5% Pd(II)/C(eggshell); hydrogen / methanol / 24 h / 20 °C / 760.05 Torr

3.1: methanol

With hydrogenchloride; 5% Pd(II)/C(eggshell); hydrogen; sodium cyanoborohydride; acetic acid; In methanol;
DOI:10.1016/j.tetasy.2011.04.002