(3S,1'R)-1,4,4-trimethyl-3-[(1-phenylethyl)amino]pyrrolidin-2-one (S)-mandelate

Base Information

Chemical Name:(3S,1'R)-1,4,4-trimethyl-3-[(1-phenylethyl)amino]pyrrolidin-2-one (S)-mandelate
CAS No.:1316216-37-1
Molecular Formula:C₈H₈O₃*C₁₅H₂₂N₂O
Molecular Weight:398.502
Hs Code.:

Synonyms:(3S,1'R)-1,4,4-trimethyl-3-[(1-phenylethyl)amino]pyrrolidin-2-one (S)-mandelate

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Chemical Property of (3S,1'R)-1,4,4-trimethyl-3-[(1-phenylethyl)amino]pyrrolidin-2-one (S)-mandelate

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Technology Process of (3S,1'R)-1,4,4-trimethyl-3-[(1-phenylethyl)amino]pyrrolidin-2-one (S)-mandelate

There total 1 articles about (3S,1'R)-1,4,4-trimethyl-3-[(1-phenylethyl)amino]pyrrolidin-2-one (S)-mandelate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1316216-36-0
(3RS,1'R)-1,4,4-trimethyl-3-[(1-phenylethyl)amino]pyrrolidin-2-one

: 17199-29-0
(S)-Mandelic acid

: 1316216-37-1
(3S,1'R)-1,4,4-trimethyl-3-[(1-phenylethyl)amino]pyrrolidin-2-one (S)-mandelate

: 1316216-38-2
(3R,1'R)-1,4,4-trimethyl-3-[(1-phenylethyl)amino]pyrrolidin-2-one (S)-mandelate

Guidance literature:: In methanol;
DOI:10.1016/j.tetasy.2011.04.002

Reference yield: 100.0%

: 1316216-37-1
(3S,1'R)-1,4,4-trimethyl-3-[(1-phenylethyl)amino]pyrrolidin-2-one (S)-mandelate

: 1316216-33-7
(3S,1'R)-1,4,4-trimethyl-3-[(1-phenylethyl)amino]pyrrolidin-2-one

Guidance literature:: With sodium hydroxide; In dichloromethane; water;
DOI:10.1016/j.tetasy.2011.04.002

Reference yield:

: 1316216-37-1
(3S,1'R)-1,4,4-trimethyl-3-[(1-phenylethyl)amino]pyrrolidin-2-one (S)-mandelate

: 1316216-35-9
(S)-N-(1,4,4-trimethylpyrrolidin-3-yl)-N'-[3,5-bis(trifluoromethyl)phenyl]thiourea

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / dichloromethane; water

2.1: hydrogenchloride; 5% Pd(II)/C(eggshell); hydrogen / methanol / 24 h / 20 °C / 760.05 Torr

3.1: borane-THF / tetrahydrofuran / 1 h / 0 °C / Reflux

3.2: 0.5 h / 20 °C

4.1: hydrogenchloride / methanol

5.1: potassium carbonate / dichloromethane / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; borane-THF; 5% Pd(II)/C(eggshell); hydrogen; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.tetasy.2011.04.002