1-((1R,2S,4R)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-4-pivalamidocyclohexyl)-3-(5-ethyl-1,3,4-thiadiazol-2-yl)urea

Base Information

Chemical Name:1-((1R,2S,4R)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-4-pivalamidocyclohexyl)-3-(5-ethyl-1,3,4-thiadiazol-2-yl)urea
CAS No.:852661-49-5
Molecular Formula:C₂₉H₄₅FN₆O₂S
Molecular Weight:560.78
Hs Code.:

Synonyms:1-((1R,2S,4R)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-4-pivalamidocyclohexyl)-3-(5-ethyl-1,3,4-thiadiazol-2-yl)urea

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Chemical Property of 1-((1R,2S,4R)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-4-pivalamidocyclohexyl)-3-(5-ethyl-1,3,4-thiadiazol-2-yl)urea

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Technology Process of 1-((1R,2S,4R)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-4-pivalamidocyclohexyl)-3-(5-ethyl-1,3,4-thiadiazol-2-yl)urea

There total 21 articles about 1-((1R,2S,4R)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-4-pivalamidocyclohexyl)-3-(5-ethyl-1,3,4-thiadiazol-2-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 606129-66-2
(5-ethyl-[1,3,4]thiadiazol-2-yl)-carbamic acid phenyl ester

: 852661-47-3
N-((1R,3S,4R)-4-amino-3-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-cyclohexyl)pivalamide

: 852661-49-5
1-((1R,2S,4R)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-4-pivalamidocyclohexyl)-3-(5-ethyl-1,3,4-thiadiazol-2-yl)urea

Guidance literature:: In tetrahydrofuran; at 20 ℃;

Reference yield:

: 459-31-4
3-(4-fluorophenyl)propanoic acid

: 852661-49-5
1-((1R,2S,4R)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-4-pivalamidocyclohexyl)-3-(5-ethyl-1,3,4-thiadiazol-2-yl)urea

Guidance literature:: Multi-step reaction with 9 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0 °C

1.2: 0.5 h

2.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 °C

3.1: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

4.1: sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

5.1: hydrogenchloride / water; acetone

6.1: ammonium acetate / methanol

6.2: 20 °C

7.1: triethylamine / dichloromethane / 0.5 h / 0 °C

8.1: hydrogen / palladium 10% on activated carbon / methanol / 20 h / 20 °C / 3102.97 Torr

9.1: tetrahydrofuran / 20 °C

With 4-methyl-morpholine; hydrogenchloride; lithium aluminium tetrahydride; ammonium acetate; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; isobutyl chloroformate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetone;

Reference yield:

: 7116-38-3
ethyl 3-(4-fluorophenyl)propanoate

: 852661-49-5
1-((1R,2S,4R)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-4-pivalamidocyclohexyl)-3-(5-ethyl-1,3,4-thiadiazol-2-yl)urea

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydroxide; water / methanol / Heating / reflux

1.2: pH 1

2.1: thionyl chloride / dichloromethane / 24 h / 25 °C

3.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Heating / reflux

5.1: sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

6.1: hydrogenchloride / water; acetone

7.1: ammonium acetate / methanol

7.2: 20 °C

8.1: triethylamine / dichloromethane / 0.5 h / 0 °C

9.1: hydrogen / palladium 10% on activated carbon / methanol / 20 h / 20 °C / 3102.97 Torr

10.1: tetrahydrofuran / 20 °C

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; ammonium acetate; water; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; acetone;