N-((1R,3S,4R)-4-amino-3-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-cyclohexyl)pivalamide

Base Information

Chemical Name:N-((1R,3S,4R)-4-amino-3-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-cyclohexyl)pivalamide
CAS No.:852661-47-3
Molecular Formula:C₂₄H₄₀FN₃O
Molecular Weight:405.6
Hs Code.:

Synonyms:N-((1R,3S,4R)-4-amino-3-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-cyclohexyl)pivalamide

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Chemical Property of N-((1R,3S,4R)-4-amino-3-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-cyclohexyl)pivalamide

Chemical Property:

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Technology Process of N-((1R,3S,4R)-4-amino-3-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-cyclohexyl)pivalamide

There total 22 articles about N-((1R,3S,4R)-4-amino-3-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-cyclohexyl)pivalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852661-46-2
benzyl (1R,2S,4R)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-4-pivalamidocyclohexylcarbamate

: 852661-47-3
N-((1R,3S,4R)-4-amino-3-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-cyclohexyl)pivalamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 20h; under 3102.97 Torr;

Reference yield:

: 459-31-4
3-(4-fluorophenyl)propanoic acid

: 852661-47-3
N-((1R,3S,4R)-4-amino-3-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-cyclohexyl)pivalamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0 °C

1.2: 0.5 h

2.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 °C

3.1: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

4.1: sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

5.1: hydrogenchloride / water; acetone

6.1: ammonium acetate / methanol

6.2: 20 °C

7.1: triethylamine / dichloromethane / 0.5 h / 0 °C

8.1: hydrogen / palladium 10% on activated carbon / methanol / 20 h / 20 °C / 3102.97 Torr

With 4-methyl-morpholine; hydrogenchloride; lithium aluminium tetrahydride; ammonium acetate; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; isobutyl chloroformate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetone;

Reference yield:

: 7116-38-3
ethyl 3-(4-fluorophenyl)propanoate

: 852661-47-3
N-((1R,3S,4R)-4-amino-3-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-cyclohexyl)pivalamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydroxide; water / methanol / Heating / reflux

1.2: pH 1

2.1: thionyl chloride / dichloromethane / 24 h / 25 °C

3.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Heating / reflux

5.1: sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

6.1: hydrogenchloride / water; acetone

7.1: ammonium acetate / methanol

7.2: 20 °C

8.1: triethylamine / dichloromethane / 0.5 h / 0 °C

9.1: hydrogen / palladium 10% on activated carbon / methanol / 20 h / 20 °C / 3102.97 Torr

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; ammonium acetate; water; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; acetone;