methyl (2S,4S)-5-methoxymethoxy-4-(4-phenoxybenzoyl)amino-2-propylpentanoate

Base Information

Chemical Name:methyl (2S,4S)-5-methoxymethoxy-4-(4-phenoxybenzoyl)amino-2-propylpentanoate
CAS No.:911050-67-4
Molecular Formula:C₂₄H₃₁NO₆
Molecular Weight:429.513
Hs Code.:

Synonyms:methyl (2S,4S)-5-methoxymethoxy-4-(4-phenoxybenzoyl)amino-2-propylpentanoate

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Chemical Property of methyl (2S,4S)-5-methoxymethoxy-4-(4-phenoxybenzoyl)amino-2-propylpentanoate

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Technology Process of methyl (2S,4S)-5-methoxymethoxy-4-(4-phenoxybenzoyl)amino-2-propylpentanoate

There total 4 articles about methyl (2S,4S)-5-methoxymethoxy-4-(4-phenoxybenzoyl)amino-2-propylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911051-03-1
(S)-4-Amino-5-methoxymethoxy-pentanoic acid methyl ester

: 911050-67-4
methyl (2S,4S)-5-methoxymethoxy-4-(4-phenoxybenzoyl)amino-2-propylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4.47 g / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; 1-hydroxybenzotriazole monohydrate; triethylamine / dimethylformamide / 3 h / 20 °C

2.1: lithium hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C

2.2: 93 percent / tetrahydrofuran / 3 h / -78 °C

3.1: 79 percent / hydrogen / Pd/C / methanol / 6 h

With hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.05.040

Reference yield:

: 911050-44-7
methyl (4S)-4-[(benzyloxy)carbonyl]amino-5-(methoxymethoxy)pentanoate

: 911050-67-4
methyl (2S,4S)-5-methoxymethoxy-4-(4-phenoxybenzoyl)amino-2-propylpentanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / Pd/C / methanol / 1 h

2.1: 4.47 g / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; 1-hydroxybenzotriazole monohydrate; triethylamine / dimethylformamide / 3 h / 20 °C

3.1: lithium hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C

3.2: 93 percent / tetrahydrofuran / 3 h / -78 °C

4.1: 79 percent / hydrogen / Pd/C / methanol / 6 h

With hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.05.040

Reference yield:

: 911050-45-8
methyl (4S)-5-methoxymethoxy-4-[(4-phenoxybenzoyl)amino]pentanoate

: 911050-67-4
methyl (2S,4S)-5-methoxymethoxy-4-(4-phenoxybenzoyl)amino-2-propylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C

1.2: 93 percent / tetrahydrofuran / 3 h / -78 °C

2.1: 79 percent / hydrogen / Pd/C / methanol / 6 h

With hydrogen; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2006.05.040