(2S,4S)-5-methoxymethoxy-4-[(4-phenoxybenzoyl)amino]-2-propylpentanoic acid

Base Information

Chemical Name:(2S,4S)-5-methoxymethoxy-4-[(4-phenoxybenzoyl)amino]-2-propylpentanoic acid
CAS No.:911050-80-1
Molecular Formula:C₂₃H₂₉NO₆
Molecular Weight:415.486
Hs Code.:

Synonyms:(2S,4S)-5-methoxymethoxy-4-[(4-phenoxybenzoyl)amino]-2-propylpentanoic acid

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Chemical Property of (2S,4S)-5-methoxymethoxy-4-[(4-phenoxybenzoyl)amino]-2-propylpentanoic acid

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Technology Process of (2S,4S)-5-methoxymethoxy-4-[(4-phenoxybenzoyl)amino]-2-propylpentanoic acid

There total 6 articles about (2S,4S)-5-methoxymethoxy-4-[(4-phenoxybenzoyl)amino]-2-propylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 911050-67-4
methyl (2S,4S)-5-methoxymethoxy-4-(4-phenoxybenzoyl)amino-2-propylpentanoate

: 911050-80-1
(2S,4S)-5-methoxymethoxy-4-[(4-phenoxybenzoyl)amino]-2-propylpentanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 4h;
DOI:10.1016/j.bmc.2006.05.040

Reference yield:

: 911051-03-1
(S)-4-Amino-5-methoxymethoxy-pentanoic acid methyl ester

: 911050-80-1
(2S,4S)-5-methoxymethoxy-4-[(4-phenoxybenzoyl)amino]-2-propylpentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4.47 g / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; 1-hydroxybenzotriazole monohydrate; triethylamine / dimethylformamide / 3 h / 20 °C

2.1: lithium hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C

2.2: 93 percent / tetrahydrofuran / 3 h / -78 °C

3.1: 79 percent / hydrogen / Pd/C / methanol / 6 h

4.1: 100 percent / NaOH / tetrahydrofuran; methanol; H₂O / 4 h / 20 °C

With sodium hydroxide; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.05.040

Reference yield:

: 911050-44-7
methyl (4S)-4-[(benzyloxy)carbonyl]amino-5-(methoxymethoxy)pentanoate

: 911050-80-1
(2S,4S)-5-methoxymethoxy-4-[(4-phenoxybenzoyl)amino]-2-propylpentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / Pd/C / methanol / 1 h

2.1: 4.47 g / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; 1-hydroxybenzotriazole monohydrate; triethylamine / dimethylformamide / 3 h / 20 °C

3.1: lithium hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C

3.2: 93 percent / tetrahydrofuran / 3 h / -78 °C

4.1: 79 percent / hydrogen / Pd/C / methanol / 6 h

5.1: 100 percent / NaOH / tetrahydrofuran; methanol; H₂O / 4 h / 20 °C

With sodium hydroxide; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.05.040