2-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethanol

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Chemical Name:2-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethanol
CAS No.:1346176-22-4
Molecular Formula:C₂₄H₂₂ClF₃N₄O₃
Molecular Weight:506.912
Hs Code.:

Synonyms:2-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethanol

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Chemical Property of 2-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethanol

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Technology Process of 2-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethanol

There total 7 articles about 2-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1346176-25-7
2-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethyl benzoate

: 1346176-22-4
2-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethanol

Guidance literature:: 2-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethyl benzoate; With sodium hydroxide; In methanol; at 20 ℃; for 2h;

With hydrogenchloride; In methanol; water;
DOI:10.1021/jm2008634

Reference yield:

: 871027-25-7
4-phenoxy-6-prop-1-yn-1-ylpyrimidin-5-amine

: 1346176-22-4
2-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / tetrahydrofuran / 0.67 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 21 h / 60 °C

3: pyridine hydrochloride; phenol / 17 h / 140 °C

4: sodium hydroxide / methanol / 2 h / 20 °C

With potassium tert-butylate; pyridine hydrochloride; potassium carbonate; sodium hydroxide; phenol; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm2008634

Reference yield:

: 871027-26-8
6-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine

: 1346176-22-4
2-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 21 h / 60 °C

2: pyridine hydrochloride; phenol / 17 h / 140 °C

3: sodium hydroxide / methanol / 2 h / 20 °C

With pyridine hydrochloride; potassium carbonate; sodium hydroxide; phenol; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm2008634