(1R,2R,4R,6S)-2-((tert-butoxycarbonyl)amino)-4-(3-isothiocyanatopyridin-4-yl)-6-methylcyclohexyl acetate

Base Information

Chemical Name:(1R,2R,4R,6S)-2-((tert-butoxycarbonyl)amino)-4-(3-isothiocyanatopyridin-4-yl)-6-methylcyclohexyl acetate
CAS No.:1616587-15-5
Molecular Formula:C₂₀H₂₇N₃O₄S
Molecular Weight:405.518
Hs Code.:

Synonyms:(1R,2R,4R,6S)-2-((tert-butoxycarbonyl)amino)-4-(3-isothiocyanatopyridin-4-yl)-6-methylcyclohexyl acetate

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Chemical Property of (1R,2R,4R,6S)-2-((tert-butoxycarbonyl)amino)-4-(3-isothiocyanatopyridin-4-yl)-6-methylcyclohexyl acetate

Chemical Property:

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Technology Process of (1R,2R,4R,6S)-2-((tert-butoxycarbonyl)amino)-4-(3-isothiocyanatopyridin-4-yl)-6-methylcyclohexyl acetate

There total 14 articles about (1R,2R,4R,6S)-2-((tert-butoxycarbonyl)amino)-4-(3-isothiocyanatopyridin-4-yl)-6-methylcyclohexyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1R,2R,4R,6S)-4-(3-aminopyridin-4-yl)-2-((tert-butoxycarbonyl)amino)-6-methylcyclohexyl acetate

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 1616587-15-5
(1R,2R,4R,6S)-2-((tert-butoxycarbonyl)amino)-4-(3-isothiocyanatopyridin-4-yl)-6-methylcyclohexyl acetate

Guidance literature:: In tetrahydrofuran; at 60 ℃; for 2h;

Reference yield:

: (±)-(1S,5S,6S)-6-bromo-5-methyl-3-(3-nitropyridin-4-yl)-cyclohex-2-enol

: 1616587-15-5
(1R,2R,4R,6S)-2-((tert-butoxycarbonyl)amino)-4-(3-isothiocyanatopyridin-4-yl)-6-methylcyclohexyl acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h

1.2: 20 °C

2.1: ammonium hydroxide; trimethylphosphane / water; pyridine / 2 h / 20 °C

3.1: sodium hydrogencarbonate / 1,4-dioxane / 2 h / 20 °C

4.1: pyridine / 20 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 72 h / 20 °C

6.1: AD-H chiral column / isopropyl alcohol; n-heptane / Resolution of racemate

7.1: tetrahydrofuran / 2 h / 60 °C

With pyridine; ammonium hydroxide; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; sodium hydrogencarbonate; trimethylphosphane; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; n-heptane; water; ethyl acetate; isopropyl alcohol;

Reference yield:

: 1187056-15-0
(±)-4-(5-methylcyclohexa-1,3-dienyl)-3-nitropyridine

: 1616587-15-5
(1R,2R,4R,6S)-2-((tert-butoxycarbonyl)amino)-4-(3-isothiocyanatopyridin-4-yl)-6-methylcyclohexyl acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-Bromosuccinimide; water / tetrahydrofuran / 0.5 h / 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h

2.2: 20 °C

3.1: ammonium hydroxide; trimethylphosphane / water; pyridine / 2 h / 20 °C

4.1: sodium hydrogencarbonate / 1,4-dioxane / 2 h / 20 °C

5.1: pyridine / 20 °C

6.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 72 h / 20 °C

7.1: AD-H chiral column / isopropyl alcohol; n-heptane / Resolution of racemate

8.1: tetrahydrofuran / 2 h / 60 °C

With pyridine; ammonium hydroxide; N-Bromosuccinimide; palladium 10% on activated carbon; potassium tert-butylate; water; hydrogen; sodium hydrogencarbonate; trimethylphosphane; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; n-heptane; water; ethyl acetate; isopropyl alcohol;