2-(2-ethyl-8-(carbomethoxymethyloxy)-3-(o-phenylbenzyl)indolizine-1-yl)glyoxylamide

Base Information

Chemical Name:2-(2-ethyl-8-(carbomethoxymethyloxy)-3-(o-phenylbenzyl)indolizine-1-yl)glyoxylamide
CAS No.:177557-47-0
Molecular Formula:C₂₈H₂₆N₂O₅
Molecular Weight:470.525
Hs Code.:

Synonyms:2-(2-ethyl-8-(carbomethoxymethyloxy)-3-(o-phenylbenzyl)indolizine-1-yl)glyoxylamide

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Chemical Property of 2-(2-ethyl-8-(carbomethoxymethyloxy)-3-(o-phenylbenzyl)indolizine-1-yl)glyoxylamide

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Technology Process of 2-(2-ethyl-8-(carbomethoxymethyloxy)-3-(o-phenylbenzyl)indolizine-1-yl)glyoxylamide

There total 9 articles about 2-(2-ethyl-8-(carbomethoxymethyloxy)-3-(o-phenylbenzyl)indolizine-1-yl)glyoxylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 96-32-2
bromoacetic acid methyl ester

: 177559-40-9
2-(2-ethyl-8-hydroxy-3-(o-phenylbenzyl)indolizine-1-yl)glyoxylamide

: 177557-47-0
2-(2-ethyl-8-(carbomethoxymethyloxy)-3-(o-phenylbenzyl)indolizine-1-yl)glyoxylamide

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; for 5h;
DOI:10.1021/jm960395q

Reference yield:

: 1121-25-1,55780-69-3
2-methyl-3-pyridinol

: 177557-47-0
2-(2-ethyl-8-(carbomethoxymethyloxy)-3-(o-phenylbenzyl)indolizine-1-yl)glyoxylamide

Guidance literature:: Multi-step reaction with 9 steps

1: 90 percent / KOH, tetrabutylammonium bromide / tetrahydrofuran / 1.5 h / Ambient temperature

2: 90.1 percent / ethyl acetate / 0.5 h / 70 °C

3: 79 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / benzene / 0.75 h / Heating

4: 80 percent / benzene / 4 h / Heating

5: NaBH₄, AlCl₃ / tetrahydrofuran / 0.75 h / Heating

6: tetrahydrofuran / 0 °C

7: aq. NH₄OH / tetrahydrofuran / Ambient temperature

8: H₂ / 10percent Pd/C / ethyl acetate

9: 54 percent / K₂CO₃, KI / dimethylformamide / 5 h

With potassium hydroxide; ammonium hydroxide; sodium tetrahydroborate; aluminium trichloride; tetrabutylammomium bromide; hydrogen; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm960395q

Reference yield:

: 177559-01-2
3-(benzyloxy)-2-methylpyridine

: 177557-47-0
2-(2-ethyl-8-(carbomethoxymethyloxy)-3-(o-phenylbenzyl)indolizine-1-yl)glyoxylamide

Guidance literature:: Multi-step reaction with 8 steps

1: 90.1 percent / ethyl acetate / 0.5 h / 70 °C

2: 79 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / benzene / 0.75 h / Heating

3: 80 percent / benzene / 4 h / Heating

4: NaBH₄, AlCl₃ / tetrahydrofuran / 0.75 h / Heating

5: tetrahydrofuran / 0 °C

6: aq. NH₄OH / tetrahydrofuran / Ambient temperature

7: H₂ / 10percent Pd/C / ethyl acetate

8: 54 percent / K₂CO₃, KI / dimethylformamide / 5 h

With ammonium hydroxide; sodium tetrahydroborate; aluminium trichloride; hydrogen; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm960395q