ethyl 2-(4-chlorophenyl)pyrazolo[1,5-a]pyridine-5-carboxylate

Base Information

• Chemical Name: ethyl 2-(4-chlorophenyl)pyrazolo[1,5-a]pyridine-5-carboxylate
• CAS No.: 1137165-35-5
• Molecular Formula: C₁₆H₁₃ClN₂O₂
• Molecular Weight: 300.744
• Mol file: 1137165-35-5.mol

Synonyms:ethyl 2-(4-chlorophenyl)pyrazolo[1,5-a]pyridine-5-carboxylate

Chemical Property of ethyl 2-(4-chlorophenyl)pyrazolo[1,5-a]pyridine-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl 2-(4-chlorophenyl)pyrazolo[1,5-a]pyridine-5-carboxylate

There total 1 articles about ethyl 2-(4-chlorophenyl)pyrazolo[1,5-a]pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-bromo-trans-crotonic acid ethyl ester (37746-78-4) + C10H7ClN2O (1024611-61-7) → ethyl 2-(4-chlorophenyl)pyrazolo[1,5-a]pyridine-5-carboxylate (1137165-35-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.3987/COM-08-11510

Reference yield: 80.0%

ethyl 2-(4-chlorophenyl)pyrazolo[1,5-a]pyridine-5-carboxylate (1137165-35-5) → 2-(4-chlorophenyl)pyrazolo[1,5-a]pyridine-5-carbohydrazide (1315454-34-2)

Guidance literature:

With hydrazine hydrate; for 6h; Reflux;

DOI:10.1016/j.dyepig.2011.03.035

Reference yield:

ethyl 2-(4-chlorophenyl)pyrazolo[1,5-a]pyridine-5-carboxylate (1137165-35-5) → 2-(4-chlorophenyl)-5-(5-phenyl-1,3,4-oxadiazol-2-yl)pyrazolo[1,5-a]pyridine (1315454-40-0)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / 6 h / Reflux

2: triethylamine / chloroform / 5 h / 20 °C

3: trichlorophosphate / 12 h / 20 °C / Reflux

With hydrazine hydrate; triethylamine; trichlorophosphate; In chloroform;

DOI:10.1016/j.dyepig.2011.03.035

upstream raw materials:

4-bromo-trans-crotonic acid ethyl ester

C₁₀H₇ClN₂O

Downstream raw materials:

2-(4-chlorophenyl)pyrazolo[1,5-a]pyridine-5-carbohydrazide

2-(4-chlorophenyl)-5-(5-phenyl-1,3,4-oxadiazol-2-yl)pyrazolo[1,5-a]pyridine