37746-78-4

Usage

Uses

Used in Organic Synthesis:
Ethyl 4-bromocrotonate is used as a key intermediate for the synthesis of various organic compounds. Its chemical properties make it a versatile building block in the creation of complex molecules and structures.
Used in Pharmaceuticals:
In the pharmaceutical industry, Ethyl 4-bromocrotonate is utilized as a starting material for the development of new drugs. Its unique structure allows for the formation of various medicinal compounds with potential therapeutic applications.
Used in Agrochemicals:
Ethyl 4-bromocrotonate is employed as a vital component in the production of agrochemicals, such as pesticides and herbicides. Its role in these products contributes to the development of more effective and targeted solutions for agricultural needs.
Used in Dyestuffs:
In the dyestuffs industry, Ethyl 4-bromocrotonate is used as an intermediate for the synthesis of various dyes and pigments. Its chemical properties enable the creation of a wide range of colors and hues, catering to the diverse requirements of the textile and other related industries.

InChI:InChI=1/C6H9BrO2/c1-2-9-6(8)4-3-5-7/h3-4H,2,5H2,1H3/b4-3+

Upstream product

• 56-23-5 tetrachloromethane 
• 128-08-5 N-Bromosuccinimide 
• 623-70-1 ethyl (E)-crotonate 
• 32224-01-4 (S)-4-bromo-3-hydroxybutyric acid,ethyl ester 
• 10544-63-5 ethyl crotonate 
• 10479-85-3 ethyl (E)-4-chlorobut-2-enoate 
• 1617-18-1 ethyl 3-butenoate 
• 24253-32-5 ethyl-2-chloro-but-3-enoate 
• 74265-40-0 ethyl 2-bromobut-3-enoate 
• 91890-87-8 DL-2-hydroxy-3-butenoic acid ethyl ester 
• 65330-90-7 Ethyl-3-acetoxy-4-bromo-butanoat 
• 65330-91-8 Ethyl-3-benzoyloxy-4-bromo-butanoat 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 17157-48-1 bromoacetaldehyde 

Downstream Products

• 64899-65-6 4-(4-chloro-2-methyl-phenoxy)-trans-crotonic acid ethyl ester 
• 113232-17-0 4-phenoxy-trans-crotonic acid ethyl ester 
• 13991-36-1 4-bromocrotonic acid 
• 24587-49-3 (2E)-4-hydroxybut-2-enoic acid 
• 10080-68-9 (E)-ethyl 4-hydroxybut-2-enoate 
• 28010-12-0 5-phenylpenta-2,4-dienoic acid 
• 114996-07-5 2E-5-hydroxy-5-phenyl-pent-2-enoic acid ethyl ester 
• 64899-51-0 4-(4-chloro-phenoxy)-trans-crotonic acid ethyl ester 
• 85692-23-5 4-anilinocrotonic acid ethyl ester 
• 1110610-35-9 5-phenyl-hexa-2t,4ξ-dienoic acid ethyl ester 
• 64899-56-5 4-(2,4,5-trichloro-phenoxy)-trans-crotonic acid ethyl ester 
• 101101-38-6 Ethyl 4-(2-oxo-1-ethoxycarbonylcyclohexyl)but-2-enoate 
• 92495-84-6 5-methyl-7t-phenyl-hepta-2t,4ξ,6-trienoic acid 
• 64899-54-3 4-(2,4-dichloro-phenoxy)-trans-crotonic acid ethyl ester 

Relevant academic research and scientific papers

Stereoselective halo-succinimide mediated γ-halogenations of substituted α-trialkylsilyl-β,γ-unsaturated esters

The halogenation of various α-ester allylsilanes with halo-succinimides (NXS, X = Cl, Br, and I) has been investigated. It has been shown that these reactions readily allow for good yields and excellent diastereoselectivities (up to >20:1) for a series of α-ester allylsilanes and halo-succinimide reagents, thereby providing a straightforward approach of preparing γ-halo-(E)-α,β-unsaturated esters.

FUNCTIONALIZED HETEROCYCLES AS ANTIVIRAL AGENTS

The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE

Compounds of formula (I') and methods of their use and preparation, as well as compositions comprising compounds of formula (I').

INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE

The present disclosure is directed to compounds of formula I and methods of their use and preparation, as well as compositions comprising compounds of formula I.

METHOD OF PREPARING AN ALKYLAMINE DERIVATIVE

The present invention provides a method of preparing an alkylamine derivates which hardly generates impurities and enables mass production with high purity.

Substituent-dictated partitioning of intermediates on the sulfide singlet oxygen reaction surface. A new mechanism for oxidative C-S bond cleavage in α-hydroperoxy sulfides

The reactions of singlet oxygen with 17 sulfides bearing either anion or radical stabilizing substituents are reported. The abilities of substituents to modify product compositions in both the oxidative cleavage and sulfide oxidation pathways are analyzed in terms of partitioning of the hydroperoxy sulfonium ylide intermediate. Evidence is presented that suggests that the hydroperoxy sulfonium ylide exists in both diradical and zwitterionic forms. In addition, both inter- and intramolecular pathways for decomposition of α-hydroperoxy sulfides are suggested to rationalize the substituent-dependent formation of oxidative C-S bond cleavage products.

Piperdine and piperazine derivatives, and antihistaminic pharmaceutical compositions containing the same

Disclosed is a compound represented by Formula (I): STR1 wherein Ar1, Ar2, n, A, B and Z are as defined in claims. Disclosed are also a process for preparing the compound and pharmaceutical compositions containing the compound. The compound has an antihistamic and antiallergic effect.

Cyclopentane derivatives manufacture

The present invention relates to new cyclopentane derivatives having the formula STR1 and to a process for their manufacture. The compounds can be used as medicaments due to their antiprostaglandin effect.