N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-2-hydroxyethanesulfonamide

Base Information

Chemical Name:N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-2-hydroxyethanesulfonamide
CAS No.:1295575-02-8
Molecular Formula:C₂₂H₂₂F₂IN₃O₆S₂
Molecular Weight:653.466
Hs Code.:

Synonyms:N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-2-hydroxyethanesulfonamide

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Chemical Property of N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-2-hydroxyethanesulfonamide

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Technology Process of N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-2-hydroxyethanesulfonamide

There total 7 articles about N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-2-hydroxyethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1295574-98-9
methyl [(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-sulfamoyl]acetate

: 1295575-02-8
N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-2-hydroxyethanesulfonamide

Guidance literature:: methyl [(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-sulfamoyl]acetate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

With ethyl acetate; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

With water; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 1295575-02-8
N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-2-hydroxyethanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 17 h / -10 - 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 48 h / 50 °C

3: pyridine / 48 h / 20 °C

4: sodium dithionite; water / tetrahydrofuran / 3 h / 50 °C

5: pyridine / 0 - 20 °C

With pyridine; sodium dithionite; water; caesium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201500442

Reference yield:

: 315-14-0
1,3,5-trifluoro-2-nitrobenzene

: 1295575-02-8
N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-2-hydroxyethanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 17 h / -10 - 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 48 h / 50 °C

3: pyridine / 48 h / 20 °C

4: sodium dithionite; water / tetrahydrofuran / 3 h / 50 °C

5: pyridine / 0 - 20 °C

With pyridine; sodium dithionite; water; caesium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201500442